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Role of sympathetic neurons in development of beta-adrenergic control of ornithine decarboxylase activity in peripheral tissues: effects of neonatal 6-hydroxydopamine treatment.

Publication ,  Journal Article
Hou, QC; Baker, FE; Seidler, FJ; Bartolome, M; Bartolome, J; Slotkin, TA
Published in: J Dev Physiol
March 1989

Sympathetic neurons are thought to regulate the development of their postsynaptic targets. In the current study, we examined the effects of sympathectomy with 6-hydroxydopamine in neonatal rats on the ontogeny of beta-receptor binding sites and their linkage to both cyclic AMP production and ornithine decarboxylase activity. Cardiac norepinephrine levels and turnover were used to confirm the completeness and permanence of the lesion. The ability of isoproterenol, a beta-adrenergic agonist, to stimulate ornithine decarboxylase (a growth-related enzyme) in heart, lung and kidney, was reduced by neonatal sympathectomy; the effect persisted into young adulthood. The effect represented a selective uncoupling of enzyme activity from receptor activation, as receptor binding capabilities were unaffected and the linkage of beta-receptors to cyclic AMP was enhanced. Comparison of the effects of peripheral sympathectomy with those of central lesions (intracisternal 6-hydroxydopamine) confirmed the importance of sympathetic nerve terminals in determining the coupling of the receptors to ornithine decarboxylase. These data suggest that sympathetic neurons program their target organs to specific trophic responses during development.

Duke Scholars

Published In

J Dev Physiol

ISSN

0141-9846

Publication Date

March 1989

Volume

11

Issue

3

Start / End Page

139 / 146

Location

England

Related Subject Headings

  • Sympathetic Nervous System
  • Sympathectomy, Chemical
  • Receptors, Adrenergic, beta
  • Rats
  • Random Allocation
  • Pregnancy
  • Oxidopamine
  • Ornithine Decarboxylase
  • Norepinephrine
  • Neurons
 

Citation

APA
Chicago
ICMJE
MLA
NLM

Published In

J Dev Physiol

ISSN

0141-9846

Publication Date

March 1989

Volume

11

Issue

3

Start / End Page

139 / 146

Location

England

Related Subject Headings

  • Sympathetic Nervous System
  • Sympathectomy, Chemical
  • Receptors, Adrenergic, beta
  • Rats
  • Random Allocation
  • Pregnancy
  • Oxidopamine
  • Ornithine Decarboxylase
  • Norepinephrine
  • Neurons