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Glucocorticoids regulate the ontogenetic transition of adrenergic receptor subtypes in rat liver.

Publication ,  Journal Article
Huff, RA; Seidler, FJ; Slotkin, TA
Published in: Life Sci
1991

During neonatal development, adrenergic control of hepatic glucose metabolism undergoes a transition from beta-receptor to alpha 1-receptor-mediated dominance coincident with the onset of function of the hypothalamus-pituitary-adrenocortical axis at the conclusion of the third to fourth week postpartum. To determine whether glucocorticoids contribute to this switch, neonatal rats were given 1 mg/kg of dexamethasone on postnatal days 13, 14 and 15 and the adrenergic receptor population examined by radioligand binding techniques. Dexamethasone accelerated the maturational replacement of beta-receptors with the alpha 1-subtype; the loss of beta-receptors was not reversible upon discontinuing treatment. When the glucocorticoid was given earlier, on days 7, 8 and 9, similar effects were obtained, but the suppression of the beta-subtype was only temporary; treatment before parturition (gestational days 17, 18 and 19) failed to suppress beta-receptor binding. These results suggest that, during a critical period, adrenocorticosteroids provide an important signal for the transition of adrenergic control of hepatic function.

Duke Scholars

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

1991

Volume

48

Issue

11

Start / End Page

1059 / 1065

Location

Netherlands

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Rats
  • Pharmacology & Pharmacy
  • Organ Size
  • Male
  • Liver
  • Glucocorticoids
  • Female
  • Body Weight
 

Citation

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Huff, R. A., Seidler, F. J., & Slotkin, T. A. (1991). Glucocorticoids regulate the ontogenetic transition of adrenergic receptor subtypes in rat liver. Life Sci, 48(11), 1059–1065. https://doi.org/10.1016/0024-3205(91)90507-8
Huff, R. A., F. J. Seidler, and T. A. Slotkin. “Glucocorticoids regulate the ontogenetic transition of adrenergic receptor subtypes in rat liver.Life Sci 48, no. 11 (1991): 1059–65. https://doi.org/10.1016/0024-3205(91)90507-8.
Huff RA, Seidler FJ, Slotkin TA. Glucocorticoids regulate the ontogenetic transition of adrenergic receptor subtypes in rat liver. Life Sci. 1991;48(11):1059–65.
Huff, R. A., et al. “Glucocorticoids regulate the ontogenetic transition of adrenergic receptor subtypes in rat liver.Life Sci, vol. 48, no. 11, 1991, pp. 1059–65. Pubmed, doi:10.1016/0024-3205(91)90507-8.
Huff RA, Seidler FJ, Slotkin TA. Glucocorticoids regulate the ontogenetic transition of adrenergic receptor subtypes in rat liver. Life Sci. 1991;48(11):1059–1065.
Journal cover image

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

1991

Volume

48

Issue

11

Start / End Page

1059 / 1065

Location

Netherlands

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Rats
  • Pharmacology & Pharmacy
  • Organ Size
  • Male
  • Liver
  • Glucocorticoids
  • Female
  • Body Weight