Glucocorticoids regulate the ontogenetic transition of adrenergic receptor subtypes in rat liver.

Published

Journal Article

During neonatal development, adrenergic control of hepatic glucose metabolism undergoes a transition from beta-receptor to alpha 1-receptor-mediated dominance coincident with the onset of function of the hypothalamus-pituitary-adrenocortical axis at the conclusion of the third to fourth week postpartum. To determine whether glucocorticoids contribute to this switch, neonatal rats were given 1 mg/kg of dexamethasone on postnatal days 13, 14 and 15 and the adrenergic receptor population examined by radioligand binding techniques. Dexamethasone accelerated the maturational replacement of beta-receptors with the alpha 1-subtype; the loss of beta-receptors was not reversible upon discontinuing treatment. When the glucocorticoid was given earlier, on days 7, 8 and 9, similar effects were obtained, but the suppression of the beta-subtype was only temporary; treatment before parturition (gestational days 17, 18 and 19) failed to suppress beta-receptor binding. These results suggest that, during a critical period, adrenocorticosteroids provide an important signal for the transition of adrenergic control of hepatic function.

Full Text

Duke Authors

Cited Authors

  • Huff, RA; Seidler, FJ; Slotkin, TA

Published Date

  • 1991

Published In

Volume / Issue

  • 48 / 11

Start / End Page

  • 1059 - 1065

PubMed ID

  • 1847731

Pubmed Central ID

  • 1847731

International Standard Serial Number (ISSN)

  • 0024-3205

Digital Object Identifier (DOI)

  • 10.1016/0024-3205(91)90507-8

Language

  • eng

Conference Location

  • Netherlands