Prenatal reserpine administration: permanent changes in adrenal tyrosine hydroxylase and dopamine beta-hydroxylase.

Journal Article (Journal Article)

Reserpine (1 mg/kg) was administered to pregnant rats on days 12, 13 and 14 of gestation. Although adrenal tyrosine hydroxylase and dopamine beta-hydroxylase activities were normal in the offspring at 4 days of postnatal age, both were elevated by 17 days and the elevations persisted into adulthood. The changes may result from permanently increased sympatho-adrenal stimulation.

Full Text

Duke Authors

Cited Authors

  • Bartolomé, J; Slotkin, TA

Published Date

  • 1975

Published In

Volume / Issue

  • 1 / 5

Start / End Page

  • 465 - 472

PubMed ID

  • 7001

International Standard Serial Number (ISSN)

  • 0098-616X


  • eng

Conference Location

  • United States