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Prenatal reserpine administration: permanent changes in adrenal tyrosine hydroxylase and dopamine beta-hydroxylase.

Publication ,  Journal Article
Bartolomé, J; Slotkin, TA
Published in: Psychopharmacol Commun
1975

Reserpine (1 mg/kg) was administered to pregnant rats on days 12, 13 and 14 of gestation. Although adrenal tyrosine hydroxylase and dopamine beta-hydroxylase activities were normal in the offspring at 4 days of postnatal age, both were elevated by 17 days and the elevations persisted into adulthood. The changes may result from permanently increased sympatho-adrenal stimulation.

Duke Scholars

Published In

Psychopharmacol Commun

ISSN

0098-616X

Publication Date

1975

Volume

1

Issue

5

Start / End Page

465 / 472

Location

United States

Related Subject Headings

  • Tyrosine 3-Monooxygenase
  • Stimulation, Chemical
  • Reserpine
  • Pregnancy
  • Female
  • Dopamine beta-Hydroxylase
  • Body Weight
  • Animals
  • Adrenal Glands
 

Citation

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Bartolomé, J., & Slotkin, T. A. (1975). Prenatal reserpine administration: permanent changes in adrenal tyrosine hydroxylase and dopamine beta-hydroxylase. Psychopharmacol Commun, 1(5), 465–472.
Bartolomé, J., and T. A. Slotkin. “Prenatal reserpine administration: permanent changes in adrenal tyrosine hydroxylase and dopamine beta-hydroxylase.Psychopharmacol Commun 1, no. 5 (1975): 465–72.
Bartolomé, J., and T. A. Slotkin. “Prenatal reserpine administration: permanent changes in adrenal tyrosine hydroxylase and dopamine beta-hydroxylase.Psychopharmacol Commun, vol. 1, no. 5, 1975, pp. 465–72.

Published In

Psychopharmacol Commun

ISSN

0098-616X

Publication Date

1975

Volume

1

Issue

5

Start / End Page

465 / 472

Location

United States

Related Subject Headings

  • Tyrosine 3-Monooxygenase
  • Stimulation, Chemical
  • Reserpine
  • Pregnancy
  • Female
  • Dopamine beta-Hydroxylase
  • Body Weight
  • Animals
  • Adrenal Glands