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Thyroid hormone differentially regulates cellular development in neonatal rat heart and kidney.

Publication ,  Journal Article
Slotkin, TA; Seidler, FJ; Kavlock, RJ; Bartolome, JV
Published in: Teratology
March 1992

The role of thyroid hormone in the control of cardiac and renal cell development was examined in neonatal rats made hyperthyroid by administration of triiodothyronine (T3, 0.1 mg/kg s.c. on postnatal days 1-5) or hypothyroid by administration of propylthiouracil (PTU, 20 mg/kg s.c. given to dams on gestational day 17 through postnatal day 5 and to pups on postnatal days 1-5). Indices of total cell number (total DNA per tissue), cell packing density (DNA per g tissue), and relative cell size (protein/DNA ratio) were evaluated from birth through young adulthood. PTU administration led to primary shortfalls in cell number that were of similar magnitude in both tissues, but persisted somewhat longer in the kidney than in the heart. Deficits in cell packing density and cell size in the hypothyroid animals were secondary to the effect on cell number, displaying smaller magnitudes of effect and a lag in appearance and disappearance of the deficits compared to that for total DNA; indeed, the phase in which tissues were restoring their cell numbers was accompanied by increased cell packing density, reflecting a more rapid restitution of cell numbers than tissue weight or cell size. In contrast to the relatively similar effects of PTU on developing cardiac and renal cells, the effects of T3 were selective for the heart. Although T3 caused general growth impairment, it evoked marked cardiac overgrowth that was accompanied by a striking increase in cell number and a small increase in cell size. The cardiac hyperplasia is unique to the developing animal, as post-replicative heart cells in adult animals show only hypertrophy in response to thyroid hormone.(ABSTRACT TRUNCATED AT 250 WORDS)

Duke Scholars

Published In

Teratology

DOI

ISSN

0040-3709

Publication Date

March 1992

Volume

45

Issue

3

Start / End Page

303 / 312

Location

United States

Related Subject Headings

  • Triiodothyronine
  • Rats, Inbred Strains
  • Rats
  • Proteins
  • Propylthiouracil
  • Myocardium
  • Kidney
  • Heart
  • Genetics & Heredity
  • DNA
 

Citation

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Chicago
ICMJE
MLA
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Slotkin, T. A., Seidler, F. J., Kavlock, R. J., & Bartolome, J. V. (1992). Thyroid hormone differentially regulates cellular development in neonatal rat heart and kidney. Teratology, 45(3), 303–312. https://doi.org/10.1002/tera.1420450309
Slotkin, T. A., F. J. Seidler, R. J. Kavlock, and J. V. Bartolome. “Thyroid hormone differentially regulates cellular development in neonatal rat heart and kidney.Teratology 45, no. 3 (March 1992): 303–12. https://doi.org/10.1002/tera.1420450309.
Slotkin TA, Seidler FJ, Kavlock RJ, Bartolome JV. Thyroid hormone differentially regulates cellular development in neonatal rat heart and kidney. Teratology. 1992 Mar;45(3):303–12.
Slotkin, T. A., et al. “Thyroid hormone differentially regulates cellular development in neonatal rat heart and kidney.Teratology, vol. 45, no. 3, Mar. 1992, pp. 303–12. Pubmed, doi:10.1002/tera.1420450309.
Slotkin TA, Seidler FJ, Kavlock RJ, Bartolome JV. Thyroid hormone differentially regulates cellular development in neonatal rat heart and kidney. Teratology. 1992 Mar;45(3):303–312.

Published In

Teratology

DOI

ISSN

0040-3709

Publication Date

March 1992

Volume

45

Issue

3

Start / End Page

303 / 312

Location

United States

Related Subject Headings

  • Triiodothyronine
  • Rats, Inbred Strains
  • Rats
  • Proteins
  • Propylthiouracil
  • Myocardium
  • Kidney
  • Heart
  • Genetics & Heredity
  • DNA