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Presynaptic input regulates development of beta-adrenergic control of rat brain ornithine decarboxylase: effects of 6-hydroxydopamine or propranolol.

Publication ,  Journal Article
Wagner, JP; Seidler, FJ; Slotkin, TA
Published in: Brain Res Bull
June 1991

beta-Adrenergic control of ornithine decarboxylase (ODC) activity is exerted only during a critical period in central nervous system development, playing an important role in neurotransmitter modulation of cell replication and differentiation. The current study examines the effects of lesions caused by 6-hydroxydopamine administration to neonatal rats, or of gestational exposure to propranolol, on the subsequent development of the ODC response to beta-adrenergic stimulation elicited by an acute intracisternal challenge with isoproterenol. 6-Hydroxydopamine treatment severely attenuated the ability of isoproterenol to stimulate ODC in the cerebellum, a tissue that shows a postnatal peak of ODC reactivity. In contrast, much smaller effects were seen in the cerebral cortex, which has an earlier (pre/perinatal) peak of ODC, despite the fact that norepinephrine depletion was more persistent in the cortex. On the other hand, blockade of fetal beta-receptors by maternal propranolol infusions resulted in immediate postnatal attenuation of the ODC response in cerebral cortex, but not cerebellum. These data suggest that early exposure of beta-receptors to norepinephrine "programs" the subsequent efficiency of the receptor linkage to ODC during a critical ontogenetic period that occurs prenatally in the cerebral cortex and postnatally in the cerebellum.

Duke Scholars

Published In

Brain Res Bull

DOI

ISSN

0361-9230

Publication Date

June 1991

Volume

26

Issue

6

Start / End Page

885 / 890

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Rats, Inbred Strains
  • Rats
  • Propranolol
  • Oxidopamine
  • Ornithine Decarboxylase
  • Norepinephrine
  • Neurotoxins
  • Neurology & Neurosurgery
  • Dopamine
 

Citation

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ICMJE
MLA
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Wagner, J. P., Seidler, F. J., & Slotkin, T. A. (1991). Presynaptic input regulates development of beta-adrenergic control of rat brain ornithine decarboxylase: effects of 6-hydroxydopamine or propranolol. Brain Res Bull, 26(6), 885–890. https://doi.org/10.1016/0361-9230(91)90253-g
Wagner, J. P., F. J. Seidler, and T. A. Slotkin. “Presynaptic input regulates development of beta-adrenergic control of rat brain ornithine decarboxylase: effects of 6-hydroxydopamine or propranolol.Brain Res Bull 26, no. 6 (June 1991): 885–90. https://doi.org/10.1016/0361-9230(91)90253-g.
Wagner, J. P., et al. “Presynaptic input regulates development of beta-adrenergic control of rat brain ornithine decarboxylase: effects of 6-hydroxydopamine or propranolol.Brain Res Bull, vol. 26, no. 6, June 1991, pp. 885–90. Pubmed, doi:10.1016/0361-9230(91)90253-g.
Journal cover image

Published In

Brain Res Bull

DOI

ISSN

0361-9230

Publication Date

June 1991

Volume

26

Issue

6

Start / End Page

885 / 890

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Rats, Inbred Strains
  • Rats
  • Propranolol
  • Oxidopamine
  • Ornithine Decarboxylase
  • Norepinephrine
  • Neurotoxins
  • Neurology & Neurosurgery
  • Dopamine