Central and sympatho-adrenal responses to insulin in adult and neonatal rats.

Published

Journal Article

In the mature rat, subcutaneous administration of insulin (0.02 IU/g body wt.) produced hypoglycemia and a profound activation of the sympatho-adrenal pathway, as indicated by a marked depletion of adrenal catecholamines. Cellular glucopenia caused by administration of 2-deoxyglucose also produced a sympatho-adrenal response. In contrast, in 2-day-old rats, the systemic injection of insulin evoked only a small depletion of catecholamines even though severe hypoglycemia was present, and 2-deoxyglucose also produced a diminished response. The central administration of insulin at an equivalent dose (0.02 IU/g brain) stimulated brain ornithine decarboxylase activity in both neonates and adults, but was ineffective in evoking hypoglycemia or adrenal catecholamine release. These results suggest that: (a) direct interaction of insulin with its receptors in the central nervous system is not required for activation of the sympatho-adrenal pathway, and (b) the lack of sensitivity of neonatal adrenal catecholamine release to subcutaneous administration of insulin is likely associated with immaturity of splanchnic neurotransmission rather than with absence of central insulin receptors or impaired peripheral responsiveness to insulin.

Full Text

Duke Authors

Cited Authors

  • Lau, C; Bartolome, JV; Bartolome, MB; Slotkin, TA

Published Date

  • December 1, 1987

Published In

Volume / Issue

  • 433 / 2

Start / End Page

  • 277 - 280

PubMed ID

  • 3319047

Pubmed Central ID

  • 3319047

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0165-3806(87)90031-9

Language

  • eng

Conference Location

  • Netherlands