Effects of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, on development of brain histamine and catecholamine systems in the neonatal rat.

Published

Journal Article

Daily administration of FMH to neonatal rats produced long-lasting inhibition of histidine decarboxylase in hypothalamus and cerebral cortex and led to depletion of histamine in both brain regions. The onset of depletion was more rapid in cerebral cortex, a region in which non-neurotransmitter pools of histamine predominate in early postnatal life, appearing as early as postnatal day 3; depletion in the hypothalamus, a region rich in histaminergic neuronal projections, appeared later. No effects were seen on body or brain growth, nor was development of other biogenic amine systems affected. FMH thus provides a selective probe for examining the role of histamine in brain development.

Full Text

Duke Authors

Cited Authors

  • Slotkin, TA; Slepetis, RJ; Weigel, SJ; Whitmore, WL

Published Date

  • June 20, 1983

Published In

Volume / Issue

  • 32 / 25

Start / End Page

  • 2897 - 2903

PubMed ID

  • 6855476

Pubmed Central ID

  • 6855476

International Standard Serial Number (ISSN)

  • 0024-3205

Digital Object Identifier (DOI)

  • 10.1016/0024-3205(83)90326-0

Language

  • eng

Conference Location

  • Netherlands