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Beta adrenergic control of macromolecule synthesis in neonatal rat heart, kidney and lung: relationship to sympathetic neuronal development.

Publication ,  Journal Article
Slotkin, TA; Whitmore, WL; Orband-Miller, L; Queen, KL; Haim, K
Published in: J Pharmacol Exp Ther
October 1987

The sympathetic nervous system has been hypothesized to coordinate the timing of cellular development in peripheral tissues. In the current study, we evaluated the relationships among the ontogeny of sympathetic projections to peripheral organs, the patterns of macromolecule synthesis in those organs and the reactivity of synthetic processes to beta adrenergic stimulation by isoproterenol. The major developmental rise in norepinephrine concentration and turnover, as well as in numbers of beta receptors, occurred during the second to fourth postnatal weeks in renal and lung sympathetic pathways and slightly earlier in the cardiac-sympathetic axis. The developmental decline in DNA synthesis in heart, kidney and lung coincided with the maturation of sympathetic projections. Direct stimulation of beta receptors by the in vivo administration of isoproterenol caused acute reductions in DNA synthesis in an age-dependent manner. In the heart, isoproterenol was first able to suppress DNA synthesis at 5 days of age and a maximal effect was seen at 9 days; this early phase was characterized by a rapid time constant of coupling of beta receptors to the DNA effect (maximal effect at 6 h after isoproterenol). Reactivity was lessened by 12 days of age and thereafter displayed a longer time constant (maximal effect at 12-24 h). Reactivity of DNA synthesis to isoproterenol challenge was slightly different in kidney and lung (detectable by 2 days of age), but bore similar developmental characteristics to the pattern in the heart (peak of reactivity at 9 days and a decline in reactivity and lengthening of the time constant after 16 days).(ABSTRACT TRUNCATED AT 250 WORDS)

Duke Scholars

Published In

J Pharmacol Exp Ther

ISSN

0022-3565

Publication Date

October 1987

Volume

243

Issue

1

Start / End Page

101 / 109

Location

United States

Related Subject Headings

  • Synapses
  • Sympathetic Nervous System
  • Receptors, Adrenergic, beta
  • Rats, Inbred Strains
  • Rats
  • RNA
  • Pharmacology & Pharmacy
  • Norepinephrine
  • Neurons
  • Lung
 

Citation

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Slotkin, T. A., Whitmore, W. L., Orband-Miller, L., Queen, K. L., & Haim, K. (1987). Beta adrenergic control of macromolecule synthesis in neonatal rat heart, kidney and lung: relationship to sympathetic neuronal development. J Pharmacol Exp Ther, 243(1), 101–109.
Slotkin, T. A., W. L. Whitmore, L. Orband-Miller, K. L. Queen, and K. Haim. “Beta adrenergic control of macromolecule synthesis in neonatal rat heart, kidney and lung: relationship to sympathetic neuronal development.J Pharmacol Exp Ther 243, no. 1 (October 1987): 101–9.
Slotkin TA, Whitmore WL, Orband-Miller L, Queen KL, Haim K. Beta adrenergic control of macromolecule synthesis in neonatal rat heart, kidney and lung: relationship to sympathetic neuronal development. J Pharmacol Exp Ther. 1987 Oct;243(1):101–9.
Slotkin TA, Whitmore WL, Orband-Miller L, Queen KL, Haim K. Beta adrenergic control of macromolecule synthesis in neonatal rat heart, kidney and lung: relationship to sympathetic neuronal development. J Pharmacol Exp Ther. 1987 Oct;243(1):101–109.

Published In

J Pharmacol Exp Ther

ISSN

0022-3565

Publication Date

October 1987

Volume

243

Issue

1

Start / End Page

101 / 109

Location

United States

Related Subject Headings

  • Synapses
  • Sympathetic Nervous System
  • Receptors, Adrenergic, beta
  • Rats, Inbred Strains
  • Rats
  • RNA
  • Pharmacology & Pharmacy
  • Norepinephrine
  • Neurons
  • Lung