Cell signaling as a target and underlying mechanism for neurobehavioral teratogenesis.


Journal Article (Review)

A wide variety of drugs and chemicals elicit neurobehavioral teratogenesis. Surprisingly, however, despite the obvious differences among unrelated compounds, the behavioral outcomes often display striking similarities, such as cognitive and attentional deficits. Recent studies of drugs of abuse (heroin, nicotine, barbiturates) and environmental toxins (environmental tobacco smoke, pesticides, metals) suggest that, regardless of the originating mechanism for perturbation of brain development, disparate neuroteratogens converge downstream on common families of alterations, characterized by changes in the expression and/or activity of the cell-signaling molecules that are essential to neuronal differentiation and synaptic communication. Identification of these common targets may help in the design of pharmacologic interventions that, administered in adulthood, can reverse the impact of exposure to neurobehavioral teratogens.

Full Text

Duke Authors

Cited Authors

  • Yanai, J; Vatury, O; Slotkin, TA

Published Date

  • June 2002

Published In

Volume / Issue

  • 965 /

Start / End Page

  • 473 - 478

PubMed ID

  • 12105122

Pubmed Central ID

  • 12105122

International Standard Serial Number (ISSN)

  • 0077-8923

Digital Object Identifier (DOI)

  • 10.1111/j.1749-6632.2002.tb04188.x


  • eng

Conference Location

  • United States