Concomitant development of [3H]-dopamine and [3H]-5-hydroxytryptamine uptake systems in rat brain regions.


Journal Article

1 Synaptosomal uptake mechanisms of 5-hydroxytryptamine and dopamine were examined in cerebral cortex, corpus striatum and midbrain plus brainstem of developing rats. 2 In all regions, there was generally a parallel biphasic development of both uptake systems; the most rapid increases occurred in the first two weeks postpartum, followed by a slower rate of increase. 3 Kinetic studies with dopamine indicated that the maturation involved increases in maximal uptake without a change in the substrate Km, suggesting that there is a change in the number or terminals but not in the uptake system per se.

Full Text

Duke Authors

Cited Authors

  • Kirksey, DF; Slotkin, TA

Published Date

  • November 1, 1979

Published In

Volume / Issue

  • 67 / 3

Start / End Page

  • 387 - 391

PubMed ID

  • 497539

Pubmed Central ID

  • 497539

International Standard Serial Number (ISSN)

  • 0007-1188

Digital Object Identifier (DOI)

  • 10.1111/j.1476-5381.1979.tb08692.x


  • eng

Conference Location

  • England