Fetal terbutaline exposure causes selective postnatal increases in cerebellar alpha-adrenergic receptor binding.

Published

Journal Article

beta-Adrenergic agonists used in therapy of premature labor and asthma cross the placenta and can affect development of the fetal nervous system. In the current study, pregnant rats were given 10 mg/kg of terbutaline on gestational days 17, 18 and 19 and adrenergic receptor binding capabilities examined in brain regions of the offspring. Despite the absence of body or brain growth impairment, selective increases were seen postnatally in cerebellar alpha 1- and alpha 2-receptor subtypes, whereas the same receptor populations were decreased by small amounts in cerebral cortex and midbrain + brainstem. beta-Adrenergic receptors showed little or no change in any region. The regional and subtype selectivity are compatible with primary deficits in the development of noradrenergic projections to the cerebellum identified in previous studies and provide further evidence that therapeutic use of beta-adrenergic agonists may produce neurobehavioral teratology.

Full Text

Duke Authors

Cited Authors

  • Slotkin, TA; Kudlacz, EM; Lappi, SE; Tayyeb, MI; Seidler, FJ

Published Date

  • 1990

Published In

Volume / Issue

  • 47 / 22

Start / End Page

  • 2051 - 2057

PubMed ID

  • 2177130

Pubmed Central ID

  • 2177130

International Standard Serial Number (ISSN)

  • 0024-3205

Language

  • eng

Conference Location

  • Netherlands