Role of ornithine decarboxylase in cardiac growth and hypertrophy.

Journal Article (Journal Article)

Inhibition of cardiac ornithine decarboxylase (ODC) by alpha-difluoromethylornithine (DFMO) did not prevent normal cardiac growth in mature rats but attenuated isoproterenol-induced hypertrophy. Hypertrophy caused by triiodothyronine was not prevented by DFMO. There appear to be both ODC-dependent and ODC-independent processes contributing to the subcellular mechanisms associated with growth, which must be considered in the potential laboratory and clinical use of DFMO.

Full Text

Duke Authors

Cited Authors

  • Bartolome, J; Huguenard, J; Slotkin, TA

Published Date

  • November 14, 1980

Published In

Volume / Issue

  • 210 / 4471

Start / End Page

  • 793 - 794

PubMed ID

  • 6449079

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.6449079


  • eng

Conference Location

  • United States