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Generation of reactive oxygen species by xanthine derivatives in MDA-MB-231 human breast cancer cells.

Publication ,  Journal Article
Crumpton, TL; Seidler, FJ; Slotkin, TA
Published in: Breast Cancer Res Treat
March 2001

Theophylline reduces cell number in MDA-MB-231 cells through mechanisms over and above phosphodiesterase inhibition. In the current study, we used an intracellular fluorescent dye to show that theophylline and, to a much greater extent, 3-isobutyl-1-methylxanthine, evoke the generation of reactive oxygen species and also sensitize the cells to insult by other oxidants. Xanthine derivatives may therefore offer novel strategies for antitumor therapeutics.

Duke Scholars

Published In

Breast Cancer Res Treat

DOI

ISSN

0167-6806

Publication Date

March 2001

Volume

66

Issue

2

Start / End Page

143 / 146

Location

Netherlands

Related Subject Headings

  • Tumor Cells, Cultured
  • Theophylline
  • Reactive Oxygen Species
  • Phosphodiesterase Inhibitors
  • Oncology & Carcinogenesis
  • Humans
  • Female
  • Breast Neoplasms
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Crumpton, T. L., Seidler, F. J., & Slotkin, T. A. (2001). Generation of reactive oxygen species by xanthine derivatives in MDA-MB-231 human breast cancer cells. Breast Cancer Res Treat, 66(2), 143–146. https://doi.org/10.1023/a:1010603816003
Crumpton, T. L., F. J. Seidler, and T. A. Slotkin. “Generation of reactive oxygen species by xanthine derivatives in MDA-MB-231 human breast cancer cells.Breast Cancer Res Treat 66, no. 2 (March 2001): 143–46. https://doi.org/10.1023/a:1010603816003.
Crumpton TL, Seidler FJ, Slotkin TA. Generation of reactive oxygen species by xanthine derivatives in MDA-MB-231 human breast cancer cells. Breast Cancer Res Treat. 2001 Mar;66(2):143–6.
Crumpton, T. L., et al. “Generation of reactive oxygen species by xanthine derivatives in MDA-MB-231 human breast cancer cells.Breast Cancer Res Treat, vol. 66, no. 2, Mar. 2001, pp. 143–46. Pubmed, doi:10.1023/a:1010603816003.
Crumpton TL, Seidler FJ, Slotkin TA. Generation of reactive oxygen species by xanthine derivatives in MDA-MB-231 human breast cancer cells. Breast Cancer Res Treat. 2001 Mar;66(2):143–146.
Journal cover image

Published In

Breast Cancer Res Treat

DOI

ISSN

0167-6806

Publication Date

March 2001

Volume

66

Issue

2

Start / End Page

143 / 146

Location

Netherlands

Related Subject Headings

  • Tumor Cells, Cultured
  • Theophylline
  • Reactive Oxygen Species
  • Phosphodiesterase Inhibitors
  • Oncology & Carcinogenesis
  • Humans
  • Female
  • Breast Neoplasms
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences