Generation of reactive oxygen species by xanthine derivatives in MDA-MB-231 human breast cancer cells.
Theophylline reduces cell number in MDA-MB-231 cells through mechanisms over and above phosphodiesterase inhibition. In the current study, we used an intracellular fluorescent dye to show that theophylline and, to a much greater extent, 3-isobutyl-1-methylxanthine, evoke the generation of reactive oxygen species and also sensitize the cells to insult by other oxidants. Xanthine derivatives may therefore offer novel strategies for antitumor therapeutics.
Crumpton, TL; Seidler, FJ; Slotkin, TA
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