Generation of reactive oxygen species by xanthine derivatives in MDA-MB-231 human breast cancer cells.

Journal Article (Journal Article)

Theophylline reduces cell number in MDA-MB-231 cells through mechanisms over and above phosphodiesterase inhibition. In the current study, we used an intracellular fluorescent dye to show that theophylline and, to a much greater extent, 3-isobutyl-1-methylxanthine, evoke the generation of reactive oxygen species and also sensitize the cells to insult by other oxidants. Xanthine derivatives may therefore offer novel strategies for antitumor therapeutics.

Full Text

Duke Authors

Cited Authors

  • Crumpton, TL; Seidler, FJ; Slotkin, TA

Published Date

  • March 2001

Published In

Volume / Issue

  • 66 / 2

Start / End Page

  • 143 - 146

PubMed ID

  • 11437100

International Standard Serial Number (ISSN)

  • 0167-6806

Digital Object Identifier (DOI)

  • 10.1023/a:1010603816003


  • eng

Conference Location

  • Netherlands