Toxic effects of maternal methadone administration on cardiac development in the neonatal rat: potential participation of altered polyamine levels in growth impairment.

Journal Article (Journal Article)

The pattern of development of polyamine levels in hearts of preweanling rats whose mothers received methadone indicated initial deficits in both spermidine and spermine followed by rebound elevations, a pattern consistent with delayed cellular development. Since polyamines are thought to play important roles in nucleic acid and protein synthesis during cellular maturation, these alterations may participate in the retardation of tissue growth seen in the perinatal opiate syndrome.

Full Text

Duke Authors

Cited Authors

  • Slotkin, TA; Weigel, SJ; Seidler, FJ; Whitmore, WL

Published Date

  • December 1, 1982

Published In

Volume / Issue

  • 14 / 3-4

Start / End Page

  • 131 - 135

PubMed ID

  • 7167972

International Standard Serial Number (ISSN)

  • 0378-4274

Digital Object Identifier (DOI)

  • 10.1016/0378-4274(82)90041-8


  • eng

Conference Location

  • Netherlands