Non-neurogenic adrenal catecholamine release in the neonatal rat: exocytosis or diffusion?

Journal Article (Journal Article)

When subjected to stress, neonatal rats secrete adrenal catecholamines by a mechanism which does not require nerve stimulation. To test whether the non-neurogenic secretory mechanism involves exocytosis, we examined the effects of hypoxia (a non-neurogenic stimulus) and nicotine (a stimulus which simulates neurogenic input) on catecholamine levels and on the uptake of [3H]epinephrine into chromaffin granules. Hypoxia- and nicotine-induced depletion of catecholamines were both accompanied by a reduction in uptake, indicating a loss of granule integrity which is characteristic of exocytosis. Although a significant proportion of adrenal catecholamines was found to be extragranular, only the granular pool was involved in the secretory response.

Full Text

Duke Authors

Cited Authors

  • Seidler, FJ; Slotkin, TA

Published Date

  • August 1986

Published In

Volume / Issue

  • 393 / 2

Start / End Page

  • 274 - 277

PubMed ID

  • 3742244

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0165-3806(86)90031-3


  • eng

Conference Location

  • Netherlands