Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease: implications for etiology and therapy.

Published

Journal Article

Brain regions from patients with or without Alzheimer disease (AD) were obtained within 2 hr of death and examined for indices of presynaptic cholinergic function. Consistent with loss of cholinergic projections, cerebral cortical areas involved in AD exhibited decreased choline acetyltransferase (acetyl-CoA:choline O-acetyltransferase, EC 2.3.1.6) activity. However, remaining nerve terminals in these regions displayed marked up-regulation of synaptosomal high affinity [3H]choline uptake, a result indicative of relative cholinergic hyperactivity. As choline uptake is also rate-limiting in acetylcholine biosynthesis, these findings have implications for both therapy and identification of causes contributing to neuronal death in AD.

Full Text

Duke Authors

Cited Authors

  • Slotkin, TA; Seidler, FJ; Crain, BJ; Bell, JM; Bissette, G; Nemeroff, CB

Published Date

  • April 1990

Published In

Volume / Issue

  • 87 / 7

Start / End Page

  • 2452 - 2455

PubMed ID

  • 2320567

Pubmed Central ID

  • 2320567

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.87.7.2452

Language

  • eng

Conference Location

  • United States