Adrenergic control of DNA synthesis in developing rat brain regions: effects of intracisternal administration of isoproterenol.

Journal Article (Journal Article)

Catecholamines are hypothesized to control cellular development in the central nervous system. In the current study, isoproterenol administered intracisternally to neonatal rats was found to inhibit DNA synthesis [( 3H]thymidine incorporation) in brain regions. The regional selectivity of effect corresponded to the sequence of cellular maturation, namely midbrain + brainstem greater than cerebral cortex greater than cerebellum, suggesting that the specific linkage of beta-adrenergic receptors to cessation of cell replication occurs during a specific maturational stage.

Full Text

Duke Authors

Cited Authors

  • Slotkin, TA; Windh, R; Whitmore, WL; Seidler, FJ

Published Date

  • November 1988

Published In

Volume / Issue

  • 21 / 5

Start / End Page

  • 737 - 740

PubMed ID

  • 3219605

International Standard Serial Number (ISSN)

  • 0361-9230

Digital Object Identifier (DOI)

  • 10.1016/0361-9230(88)90040-8


  • eng

Conference Location

  • United States