Skip to main content
Journal cover image

Prenatal terbutaline exposure in the rat: selective effects on development of noradrenergic projections to cerebellum.

Publication ,  Journal Article
Slotkin, TA; Baker, FE; Dobbins, SS; Eylers, JP; Lappi, SE; Seidler, FJ
Published in: Brain Res Bull
1989

Terbutaline, used in the treatment of premature labor and asthma, crosses the placenta and can stimulate beta 2-adrenergic receptors in the fetus. This study examines the effects of prenatal exposure to terbutaline (10 mg/kg SC on gestational days 17, 18 and 19) on the development of noradrenergic projections in brain regions of the fetal and neonatal rat, using synaptosomal uptake of [3H]norepinephrine as a marker for synaptogenesis. Although terbutaline exposure did not compromise body or brain region growth, uptake was adversely affected selectively in the cerebellum, a region which also displays close coupling of fetal beta 2-receptors to control of cell development near term. These results thus provide biochemical evidence that terbutaline may be a neurobehavioral teratogen.

Duke Scholars

Published In

Brain Res Bull

DOI

ISSN

0361-9230

Publication Date

1989

Volume

23

Issue

4-5

Start / End Page

263 / 265

Location

United States

Related Subject Headings

  • Terbutaline
  • Rats, Inbred Strains
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Norepinephrine
  • Neurology & Neurosurgery
  • Female
  • Embryonic and Fetal Development
  • Cerebellum
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Slotkin, T. A., Baker, F. E., Dobbins, S. S., Eylers, J. P., Lappi, S. E., & Seidler, F. J. (1989). Prenatal terbutaline exposure in the rat: selective effects on development of noradrenergic projections to cerebellum. Brain Res Bull, 23(4–5), 263–265. https://doi.org/10.1016/0361-9230(89)90206-2
Slotkin, T. A., F. E. Baker, S. S. Dobbins, J. P. Eylers, S. E. Lappi, and F. J. Seidler. “Prenatal terbutaline exposure in the rat: selective effects on development of noradrenergic projections to cerebellum.Brain Res Bull 23, no. 4–5 (1989): 263–65. https://doi.org/10.1016/0361-9230(89)90206-2.
Slotkin TA, Baker FE, Dobbins SS, Eylers JP, Lappi SE, Seidler FJ. Prenatal terbutaline exposure in the rat: selective effects on development of noradrenergic projections to cerebellum. Brain Res Bull. 1989;23(4–5):263–5.
Slotkin, T. A., et al. “Prenatal terbutaline exposure in the rat: selective effects on development of noradrenergic projections to cerebellum.Brain Res Bull, vol. 23, no. 4–5, 1989, pp. 263–65. Pubmed, doi:10.1016/0361-9230(89)90206-2.
Slotkin TA, Baker FE, Dobbins SS, Eylers JP, Lappi SE, Seidler FJ. Prenatal terbutaline exposure in the rat: selective effects on development of noradrenergic projections to cerebellum. Brain Res Bull. 1989;23(4–5):263–265.
Journal cover image

Published In

Brain Res Bull

DOI

ISSN

0361-9230

Publication Date

1989

Volume

23

Issue

4-5

Start / End Page

263 / 265

Location

United States

Related Subject Headings

  • Terbutaline
  • Rats, Inbred Strains
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Norepinephrine
  • Neurology & Neurosurgery
  • Female
  • Embryonic and Fetal Development
  • Cerebellum