Prenatal terbutaline exposure in the rat: selective effects on development of noradrenergic projections to cerebellum.

Journal Article (Journal Article)

Terbutaline, used in the treatment of premature labor and asthma, crosses the placenta and can stimulate beta 2-adrenergic receptors in the fetus. This study examines the effects of prenatal exposure to terbutaline (10 mg/kg SC on gestational days 17, 18 and 19) on the development of noradrenergic projections in brain regions of the fetal and neonatal rat, using synaptosomal uptake of [3H]norepinephrine as a marker for synaptogenesis. Although terbutaline exposure did not compromise body or brain region growth, uptake was adversely affected selectively in the cerebellum, a region which also displays close coupling of fetal beta 2-receptors to control of cell development near term. These results thus provide biochemical evidence that terbutaline may be a neurobehavioral teratogen.

Full Text

Duke Authors

Cited Authors

  • Slotkin, TA; Baker, FE; Dobbins, SS; Eylers, JP; Lappi, SE; Seidler, FJ

Published Date

  • 1989

Published In

Volume / Issue

  • 23 / 4-5

Start / End Page

  • 263 - 265

PubMed ID

  • 2590837

International Standard Serial Number (ISSN)

  • 0361-9230

Digital Object Identifier (DOI)

  • 10.1016/0361-9230(89)90206-2


  • eng

Conference Location

  • United States