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Development of brain beta-adrenergic receptors after neonatal 6-hydroxydopamine treatment.

Publication ,  Journal Article
Lorton, D; Bartolome, J; Slotkin, TA; Davis, JN
Published in: Brain Res Bull
October 1988

We used [125I]-cyanopindolol in vitro autoradiography and neonatal 6-hydroxydopamine treatment to study the development of beta-adrenergic receptor subtypes in rat brain. Brain regions receiving locus coeruleus innervation, such as cerebral cortex and cerebellum, displayed low receptor densities at birth and increased in density rapidly during the second and fourth weeks postnatally. By contrast, regions which receive little innervation from the locus coeruleus, such as substantia nigra, striatum, and globus pallidus, displayed relatively high beta-receptor densities even at birth. The striatum appeared to be an exception to these generalizations. 6-Hydroxydopamine administration was associated with an increase in the densities of beta-receptor subtypes and, unexpectedly, with a change in the proportions of the two subtypes. These data support the view that innervation determines the ontogenetic patterns of some receptors in brain.

Duke Scholars

Published In

Brain Res Bull

DOI

ISSN

0361-9230

Publication Date

October 1988

Volume

21

Issue

4

Start / End Page

591 / 600

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Rats, Inbred Strains
  • Rats
  • Oxidopamine
  • Neurology & Neurosurgery
  • Hydroxydopamines
  • Brain
  • Autoradiography
  • Animals, Newborn
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lorton, D., Bartolome, J., Slotkin, T. A., & Davis, J. N. (1988). Development of brain beta-adrenergic receptors after neonatal 6-hydroxydopamine treatment. Brain Res Bull, 21(4), 591–600. https://doi.org/10.1016/0361-9230(88)90198-0
Lorton, D., J. Bartolome, T. A. Slotkin, and J. N. Davis. “Development of brain beta-adrenergic receptors after neonatal 6-hydroxydopamine treatment.Brain Res Bull 21, no. 4 (October 1988): 591–600. https://doi.org/10.1016/0361-9230(88)90198-0.
Lorton D, Bartolome J, Slotkin TA, Davis JN. Development of brain beta-adrenergic receptors after neonatal 6-hydroxydopamine treatment. Brain Res Bull. 1988 Oct;21(4):591–600.
Lorton, D., et al. “Development of brain beta-adrenergic receptors after neonatal 6-hydroxydopamine treatment.Brain Res Bull, vol. 21, no. 4, Oct. 1988, pp. 591–600. Pubmed, doi:10.1016/0361-9230(88)90198-0.
Lorton D, Bartolome J, Slotkin TA, Davis JN. Development of brain beta-adrenergic receptors after neonatal 6-hydroxydopamine treatment. Brain Res Bull. 1988 Oct;21(4):591–600.
Journal cover image

Published In

Brain Res Bull

DOI

ISSN

0361-9230

Publication Date

October 1988

Volume

21

Issue

4

Start / End Page

591 / 600

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Rats, Inbred Strains
  • Rats
  • Oxidopamine
  • Neurology & Neurosurgery
  • Hydroxydopamines
  • Brain
  • Autoradiography
  • Animals, Newborn
  • Animals