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Dose-dependent effect of prenatal dexamethasone treatment on beta-adrenergic receptor coupling to ornithine decarboxylase and cyclic AMP.

Publication ,  Journal Article
Bian, XP; Seidler, FJ; Bartolome, J; Kavlock, RJ; Bartolome, M; Slotkin, TA
Published in: J Dev Physiol
September 1990

Glucocorticoids regulate the coupling of beta-adrenergic receptors to cell function. In the current study, the potential role of these agents in the development of adrenergic responses was evaluated in the offspring of pregnant rats given 0.8 mg/kg of dexamethasone on gestational days 17, 18 and 19. We examined the postnatal development of beta-receptors coupling to ornithine decarboxylase in heart and kidney throughout neonatal life into young adulthood; this enzyme is involved in transduction of neural signals controlling cellular replication and differentiation. Dexamethasone exposure perturbed the basal pattern of cardiac ornithine decarboxylase activity and attenuated the response of the enzyme in both heart and kidney to acute challenge with the beta-agonist, isoproterenol. Subsensitivity persisted into the postweaning period. This dosage regimen of dexamethasone also suppressed renal cyclic AMP responses to isoproterenol, but exposure to a lower dose (0.2 mg/kg) enhanced the response. Thus, although low doses of glucocorticoids foster development of the coupling of beta-receptors to cellular transduction mechanisms, higher doses such as those used to stimulate lung function may lastingly obtund adrenergic sensitivity.

Duke Scholars

Published In

J Dev Physiol

ISSN

0141-9846

Publication Date

September 1990

Volume

14

Issue

3

Start / End Page

125 / 130

Location

England

Related Subject Headings

  • Signal Transduction
  • Receptors, Adrenergic, beta
  • Rats, Inbred Strains
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Ornithine Decarboxylase
  • Organ Size
  • Myocardium
  • Maternal-Fetal Exchange
 

Citation

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Bian, X. P., Seidler, F. J., Bartolome, J., Kavlock, R. J., Bartolome, M., & Slotkin, T. A. (1990). Dose-dependent effect of prenatal dexamethasone treatment on beta-adrenergic receptor coupling to ornithine decarboxylase and cyclic AMP. J Dev Physiol, 14(3), 125–130.
Bian, X. P., F. J. Seidler, J. Bartolome, R. J. Kavlock, M. Bartolome, and T. A. Slotkin. “Dose-dependent effect of prenatal dexamethasone treatment on beta-adrenergic receptor coupling to ornithine decarboxylase and cyclic AMP.J Dev Physiol 14, no. 3 (September 1990): 125–30.
Bian XP, Seidler FJ, Bartolome J, Kavlock RJ, Bartolome M, Slotkin TA. Dose-dependent effect of prenatal dexamethasone treatment on beta-adrenergic receptor coupling to ornithine decarboxylase and cyclic AMP. J Dev Physiol. 1990 Sep;14(3):125–30.
Bian XP, Seidler FJ, Bartolome J, Kavlock RJ, Bartolome M, Slotkin TA. Dose-dependent effect of prenatal dexamethasone treatment on beta-adrenergic receptor coupling to ornithine decarboxylase and cyclic AMP. J Dev Physiol. 1990 Sep;14(3):125–130.

Published In

J Dev Physiol

ISSN

0141-9846

Publication Date

September 1990

Volume

14

Issue

3

Start / End Page

125 / 130

Location

England

Related Subject Headings

  • Signal Transduction
  • Receptors, Adrenergic, beta
  • Rats, Inbred Strains
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Ornithine Decarboxylase
  • Organ Size
  • Myocardium
  • Maternal-Fetal Exchange