Norepinephrine content of the rat kidney during development: alterations induced by perinatal methadone.

Journal Article (Journal Article)

The concentration and the total content of norepinephrine (NE) in the kidney were measured in Sprague-Dawley rats from 3 to 120 days after birth. Renal NE concentration was relatively low until the end of the second week, when it rose abruptly to adult levels; total NE content per kidney increased steadily throughout development. The effects of perinatal methadone treatment on renal NE development were examined by administering the drug either directly to the pups from 1 to 19 days after birth, or to the mother from 10 days of gestation to 20 days after birth. Both treatments resulted in significant deficits of body weight and kidney weight. Maternal methadone caused a significant deficit in renal NE which was most pronounced at two weeks of postnatal age; direct methadone had less effect on renal NE. These results suggest that renal sympathetic neurotransmission may become mature two weeks after birth and indicate further that maternal methadone interferes with this maturation.

Full Text

Duke Authors

Cited Authors

  • Grignolo, A; Seidler, FJ; Bartolome, M; Kuhn, CM; Slotkin, TA; Schanberg, SM

Published Date

  • December 27, 1982

Published In

Volume / Issue

  • 31 / 26

Start / End Page

  • 3009 - 3016

PubMed ID

  • 7162362

Pubmed Central ID

  • 7162362

International Standard Serial Number (ISSN)

  • 0024-3205

Digital Object Identifier (DOI)

  • 10.1016/0024-3205(82)90068-6


  • eng

Conference Location

  • Netherlands