Immediate decline in DNA synthesis in neonatal rat lung caused by exposure to 100% oxygen.

Journal Article (Journal Article)

Oxygen therapy in preterm infants is associated with bronchopulmonary dysplasia, but the relative importance of oxygen toxicity as compared to adverse effects of intubation and mechanical ventilation, remains uncertain. In freely-breathing neonatal rats, exposure to 100% oxygen for as little as 2 hr produced a significant reduction in lung DNA synthesis, evaluated by [3H]thymidine incorporation, without a concomitant effect on [3H]leucine incorporation into protein. These results indicate that hyperoxia has a selective deleterious effect on mitosis in developing lung.

Full Text

Duke Authors

Cited Authors

  • Wood, MW; Seidler, FJ; Slotkin, TA

Published Date

  • June 1993

Published In

Volume / Issue

  • 80 / 3

Start / End Page

  • 323 - 328

PubMed ID

  • 8351412

International Standard Serial Number (ISSN)

  • 0034-5164


  • eng

Conference Location

  • United States