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Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain.

Publication ,  Journal Article
Slotkin, TA; Pinkerton, KE; Auman, JT; Qiao, D; Seidler, FJ
Published in: Brain Res Dev Brain Res
February 28, 2002

In humans, perinatal exposure to environmental tobacco smoke (ETS) is associated with neurobehavioral deficits. In the current study, we exposed Rhesus monkeys to ETS in late gestation and in the early neonatal period, and examined changes in neurotransmitter receptors in the brainstem and caudal portion of the cerebral cortex. Nicotinic acetylcholine receptors were markedly upregulated and the effect was selective in that there were no changes in m(2)-muscarinic acetylcholine receptors or in beta-adrenergic receptors. Nicotinic receptor upregulation is indicative of chronic cell stimulation by nicotine, and is a hallmark of nicotine-induced neuroteratogenesis. These results indicate that perinatal ETS exposes the fetus and neonate to quantities of nicotine that are sufficient to alter brain development.

Duke Scholars

Published In

Brain Res Dev Brain Res

DOI

ISSN

0165-3806

Publication Date

February 28, 2002

Volume

133

Issue

2

Start / End Page

175 / 179

Location

Netherlands

Related Subject Headings

  • Up-Regulation
  • Tobacco Smoke Pollution
  • Synaptic Transmission
  • Sex Factors
  • Receptors, Nicotinic
  • Receptors, Muscarinic
  • Receptors, Adrenergic, beta
  • Receptor, Muscarinic M2
  • Rats, Sprague-Dawley
  • Rats
 

Citation

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Slotkin, T. A., Pinkerton, K. E., Auman, J. T., Qiao, D., & Seidler, F. J. (2002). Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain. Brain Res Dev Brain Res, 133(2), 175–179. https://doi.org/10.1016/s0165-3806(02)00281-x
Slotkin, T. A., K. E. Pinkerton, J. T. Auman, D. Qiao, and F. J. Seidler. “Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain.Brain Res Dev Brain Res 133, no. 2 (February 28, 2002): 175–79. https://doi.org/10.1016/s0165-3806(02)00281-x.
Slotkin TA, Pinkerton KE, Auman JT, Qiao D, Seidler FJ. Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain. Brain Res Dev Brain Res. 2002 Feb 28;133(2):175–9.
Slotkin, T. A., et al. “Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain.Brain Res Dev Brain Res, vol. 133, no. 2, Feb. 2002, pp. 175–79. Pubmed, doi:10.1016/s0165-3806(02)00281-x.
Slotkin TA, Pinkerton KE, Auman JT, Qiao D, Seidler FJ. Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain. Brain Res Dev Brain Res. 2002 Feb 28;133(2):175–179.
Journal cover image

Published In

Brain Res Dev Brain Res

DOI

ISSN

0165-3806

Publication Date

February 28, 2002

Volume

133

Issue

2

Start / End Page

175 / 179

Location

Netherlands

Related Subject Headings

  • Up-Regulation
  • Tobacco Smoke Pollution
  • Synaptic Transmission
  • Sex Factors
  • Receptors, Nicotinic
  • Receptors, Muscarinic
  • Receptors, Adrenergic, beta
  • Receptor, Muscarinic M2
  • Rats, Sprague-Dawley
  • Rats