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Maternal methadone administration: deficit in development of alpha-noradrenergic responses in developing rat brain as assessed by norepinephrine stimulation of 33Pi incorporation into phospholipids in vivo.

Publication ,  Journal Article
Slotkin, TA; Weigel, SJ; Whitmore, WL; Seidler, FJ
Published in: Biochem Pharmacol
May 15, 1982

The effects of perinatal methadone exposure on the development of noradrenergic responses in the brain were examined by assessing the ability of intracisternally administered norepinephrine to stimulate 33Pi incorporation into phospholipids in vivo; the effect of norepinephrine is mediated by alpha1-receptors juxtaposed to noradrenergic nerve terminals. Although there was no difference in basal (unstimulated) incorporation of 33Pi, a deficit in norepinephrine-induced stimulation of incorporation was found throughout the preweaning period in offspring of dams treated daily with methadone beginning in midgestation. This effect was not seen when methadone was given during the postnatal period. Since perinatal methadone exposure also delays development of presynaptic catecholaminergic nerve terminals in the brain, these results support the view that perinatal exposure to methadone depresses overall central noradrenergic synaptic function; however, the effects on presynaptic development and on receptor-mediated responses appear to be separable in that they display differences in the critical age periods of sensitivity to perturbation by the drug.

Duke Scholars

Published In

Biochem Pharmacol

DOI

ISSN

0006-2952

Publication Date

May 15, 1982

Volume

31

Issue

10

Start / End Page

1899 / 1902

Location

England

Related Subject Headings

  • Synapses
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic
  • Rats, Inbred Strains
  • Rats
  • Pregnancy
  • Phospholipids
  • Pharmacology & Pharmacy
  • Norepinephrine
  • Methadone
 

Citation

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Slotkin, T. A., Weigel, S. J., Whitmore, W. L., & Seidler, F. J. (1982). Maternal methadone administration: deficit in development of alpha-noradrenergic responses in developing rat brain as assessed by norepinephrine stimulation of 33Pi incorporation into phospholipids in vivo. Biochem Pharmacol, 31(10), 1899–1902. https://doi.org/10.1016/0006-2952(82)90494-4
Slotkin, T. A., S. J. Weigel, W. L. Whitmore, and F. J. Seidler. “Maternal methadone administration: deficit in development of alpha-noradrenergic responses in developing rat brain as assessed by norepinephrine stimulation of 33Pi incorporation into phospholipids in vivo.Biochem Pharmacol 31, no. 10 (May 15, 1982): 1899–1902. https://doi.org/10.1016/0006-2952(82)90494-4.
Journal cover image

Published In

Biochem Pharmacol

DOI

ISSN

0006-2952

Publication Date

May 15, 1982

Volume

31

Issue

10

Start / End Page

1899 / 1902

Location

England

Related Subject Headings

  • Synapses
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic
  • Rats, Inbred Strains
  • Rats
  • Pregnancy
  • Phospholipids
  • Pharmacology & Pharmacy
  • Norepinephrine
  • Methadone