Toxic effects of hypoxia on neonatal cardiac function in the rat: alpha-adrenergic mechanisms.

Journal Article (Journal Article)

Stimulation of peripheral alpha-adrenergic receptors by circulating catecholamines derived from the adrenal medulla is essential for surviving neonatal hypoxia. In 1-day-old rats, where sympathetic innervation of cardiovascular sites has not yet developed, blockade of these receptors results in failure of cardiac performance from a progressive decline in sinus rate and atrioventricular conduction deficits. These effects are absent in 8-day-old rats, where sympathetic efferent innervation has become established.

Full Text

Duke Authors

Cited Authors

  • Seidler, FJ; Brown, KK; Smith, PG; Slotkin, TA

Published Date

  • June 1, 1987

Published In

Volume / Issue

  • 37 / 1

Start / End Page

  • 79 - 84

PubMed ID

  • 3035753

International Standard Serial Number (ISSN)

  • 0378-4274

Digital Object Identifier (DOI)

  • 10.1016/0378-4274(87)90170-6


  • eng

Conference Location

  • Netherlands