Toxic effects of hypoxia on neonatal cardiac function in the rat: alpha-adrenergic mechanisms.
Publication
, Journal Article
Seidler, FJ; Brown, KK; Smith, PG; Slotkin, TA
Published in: Toxicol Lett
June 1987
Stimulation of peripheral alpha-adrenergic receptors by circulating catecholamines derived from the adrenal medulla is essential for surviving neonatal hypoxia. In 1-day-old rats, where sympathetic innervation of cardiovascular sites has not yet developed, blockade of these receptors results in failure of cardiac performance from a progressive decline in sinus rate and atrioventricular conduction deficits. These effects are absent in 8-day-old rats, where sympathetic efferent innervation has become established.
Duke Scholars
Published In
Toxicol Lett
DOI
ISSN
0378-4274
Publication Date
June 1987
Volume
37
Issue
1
Start / End Page
79 / 84
Location
Netherlands
Related Subject Headings
- Toxicology
- Receptors, Adrenergic, alpha
- Rats, Inbred Strains
- Rats
- Phenoxybenzamine
- Hypoxia
- Hemodynamics
- Heart Rate
- Heart
- Electrocardiography
Citation
APA
Chicago
ICMJE
MLA
NLM
Seidler, F. J., Brown, K. K., Smith, P. G., & Slotkin, T. A. (1987). Toxic effects of hypoxia on neonatal cardiac function in the rat: alpha-adrenergic mechanisms. Toxicol Lett, 37(1), 79–84. https://doi.org/10.1016/0378-4274(87)90170-6
Seidler, F. J., K. K. Brown, P. G. Smith, and T. A. Slotkin. “Toxic effects of hypoxia on neonatal cardiac function in the rat: alpha-adrenergic mechanisms.” Toxicol Lett 37, no. 1 (June 1987): 79–84. https://doi.org/10.1016/0378-4274(87)90170-6.
Seidler FJ, Brown KK, Smith PG, Slotkin TA. Toxic effects of hypoxia on neonatal cardiac function in the rat: alpha-adrenergic mechanisms. Toxicol Lett. 1987 Jun;37(1):79–84.
Seidler, F. J., et al. “Toxic effects of hypoxia on neonatal cardiac function in the rat: alpha-adrenergic mechanisms.” Toxicol Lett, vol. 37, no. 1, June 1987, pp. 79–84. Pubmed, doi:10.1016/0378-4274(87)90170-6.
Seidler FJ, Brown KK, Smith PG, Slotkin TA. Toxic effects of hypoxia on neonatal cardiac function in the rat: alpha-adrenergic mechanisms. Toxicol Lett. 1987 Jun;37(1):79–84.
Published In
Toxicol Lett
DOI
ISSN
0378-4274
Publication Date
June 1987
Volume
37
Issue
1
Start / End Page
79 / 84
Location
Netherlands
Related Subject Headings
- Toxicology
- Receptors, Adrenergic, alpha
- Rats, Inbred Strains
- Rats
- Phenoxybenzamine
- Hypoxia
- Hemodynamics
- Heart Rate
- Heart
- Electrocardiography