Toxic effects of hypoxia on neonatal cardiac function in the rat: alpha-adrenergic mechanisms.
Journal Article (Journal Article)
Stimulation of peripheral alpha-adrenergic receptors by circulating catecholamines derived from the adrenal medulla is essential for surviving neonatal hypoxia. In 1-day-old rats, where sympathetic innervation of cardiovascular sites has not yet developed, blockade of these receptors results in failure of cardiac performance from a progressive decline in sinus rate and atrioventricular conduction deficits. These effects are absent in 8-day-old rats, where sympathetic efferent innervation has become established.
Full Text
Duke Authors
Cited Authors
- Seidler, FJ; Brown, KK; Smith, PG; Slotkin, TA
Published Date
- June 1, 1987
Published In
Volume / Issue
- 37 / 1
Start / End Page
- 79 - 84
PubMed ID
- 3035753
International Standard Serial Number (ISSN)
- 0378-4274
Digital Object Identifier (DOI)
- 10.1016/0378-4274(87)90170-6
Language
- eng
Conference Location
- Netherlands