Postnatal alterations in beta-adrenergic receptor binding in rat brain regions after continuous prenatal exposure to propranolol via maternal infusion.

Published

Journal Article

Early exposure of developing postsynaptic receptors to the appropriate neurotransmitter is thought to be important for establishing the pattern of receptor development and function. We have examined the role of fetal catecholamines in central nervous system beta-adrenergic receptor maturation by administering the beta-adrenergic antagonist, propranolol, throughout gestation via continuous maternal infusion in rats. After birth, we examined beta-receptor binding of [125I]pindolol in three brain regions. In the cerebral cortex, receptor binding was relatively normal in the propranolol group during the immediate postpartum period, but eventually became elevated in young adulthood. Binding characteristics were not significantly affected in midbrain + brainstem or cerebellum. These data support a role for fetal catecholamines in the programming of subsequent receptor development, but in a fashion selective for specific brain regions.

Full Text

Duke Authors

Cited Authors

  • Kudlacz, EM; Spencer, JR; Slotkin, TA

Published Date

  • February 1991

Published In

Volume / Issue

  • 71 / 2

Start / End Page

  • 153 - 161

PubMed ID

  • 1646467

Pubmed Central ID

  • 1646467

International Standard Serial Number (ISSN)

  • 0034-5164

Language

  • eng

Conference Location

  • United States