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Postnatal alterations in beta-adrenergic receptor binding in rat brain regions after continuous prenatal exposure to propranolol via maternal infusion.

Publication ,  Journal Article
Kudlacz, EM; Spencer, JR; Slotkin, TA
Published in: Res Commun Chem Pathol Pharmacol
February 1991

Early exposure of developing postsynaptic receptors to the appropriate neurotransmitter is thought to be important for establishing the pattern of receptor development and function. We have examined the role of fetal catecholamines in central nervous system beta-adrenergic receptor maturation by administering the beta-adrenergic antagonist, propranolol, throughout gestation via continuous maternal infusion in rats. After birth, we examined beta-receptor binding of [125I]pindolol in three brain regions. In the cerebral cortex, receptor binding was relatively normal in the propranolol group during the immediate postpartum period, but eventually became elevated in young adulthood. Binding characteristics were not significantly affected in midbrain + brainstem or cerebellum. These data support a role for fetal catecholamines in the programming of subsequent receptor development, but in a fashion selective for specific brain regions.

Duke Scholars

Published In

Res Commun Chem Pathol Pharmacol

ISSN

0034-5164

Publication Date

February 1991

Volume

71

Issue

2

Start / End Page

153 / 161

Location

United States

Related Subject Headings

  • Up-Regulation
  • Receptors, Adrenergic, beta
  • Rats, Inbred Strains
  • Rats
  • Propranolol
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Pindolol
  • Organ Size
  • Membranes
 

Citation

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Kudlacz, E. M., Spencer, J. R., & Slotkin, T. A. (1991). Postnatal alterations in beta-adrenergic receptor binding in rat brain regions after continuous prenatal exposure to propranolol via maternal infusion. Res Commun Chem Pathol Pharmacol, 71(2), 153–161.
Kudlacz, E. M., J. R. Spencer, and T. A. Slotkin. “Postnatal alterations in beta-adrenergic receptor binding in rat brain regions after continuous prenatal exposure to propranolol via maternal infusion.Res Commun Chem Pathol Pharmacol 71, no. 2 (February 1991): 153–61.
Kudlacz, E. M., et al. “Postnatal alterations in beta-adrenergic receptor binding in rat brain regions after continuous prenatal exposure to propranolol via maternal infusion.Res Commun Chem Pathol Pharmacol, vol. 71, no. 2, Feb. 1991, pp. 153–61.

Published In

Res Commun Chem Pathol Pharmacol

ISSN

0034-5164

Publication Date

February 1991

Volume

71

Issue

2

Start / End Page

153 / 161

Location

United States

Related Subject Headings

  • Up-Regulation
  • Receptors, Adrenergic, beta
  • Rats, Inbred Strains
  • Rats
  • Propranolol
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Pindolol
  • Organ Size
  • Membranes