Does terbutaline damage the developing heart?

Published

Journal Article

BACKGROUND: Beta(2)-Adrenoceptor (betaAR) agonists, such as terbutaline, are widely used to arrest preterm labor. They also cross the placenta where they stimulate receptors in fetal tissues, which in turn use betaAR input for trophic control of cell replication and differentiation. METHODS: As rats are altricial, we administered terbutaline in two different postnatal exposure periods (10 mg/kg given daily on Days 2-5 or 11-14). RESULTS: Hearts were examined twenty-four hours after the last dose and on postnatal day 30 for cardiac damage. Neither treatment paradigm caused an increase in cardiac abnormalities compared to controls but quantitative analysis of the number of nuclei indicated reductions in females. CONCLUSIONS: These findings do not support earlier case reports of outright myocardial necrosis after terbutaline tocolysis in human infants. Nevertheless, the significant statistical association between terbutaline and cardiac anomalies in epidemiological studies suggest that terbutaline may sensitize the developing heart to other insults that affect development.

Full Text

Duke Authors

Cited Authors

  • Rhodes, MC; Nyska, A; Seidler, FJ; Slotkin, TA

Published Date

  • December 2003

Published In

Volume / Issue

  • 68 / 6

Start / End Page

  • 449 - 455

PubMed ID

  • 14745978

Pubmed Central ID

  • 14745978

Electronic International Standard Serial Number (EISSN)

  • 1542-9741

International Standard Serial Number (ISSN)

  • 1542-9733

Digital Object Identifier (DOI)

  • 10.1002/bdrb.10043

Language

  • eng