Phosphorylation of caldesmon by mitogen-activated protein kinase with no effect on Ca2+ sensitivity in rabbit smooth muscle.

Journal Article (Journal Article)

1. Recombinant, activated mitogen-activated protein kinase (3.3 microM; p42mapk) phosphorylated caldesmon in phasic (rabbit portal vein) and tonic (rabbit femoral artery) smooth muscle strips permeabilized with Triton X-100. 2. Phosphorylation of caldesmon by p42mapk neither induced contraction of relaxed smooth muscle nor affected the Ca2+ sensitivity of submaximally contracted permeabilized phasic or tonic smooth muscle.

Full Text

Duke Authors

Cited Authors

  • Nixon, GF; Iizuka, K; Haystead, CM; Haystead, TA; Somlyo, AP; Somlyo, AV

Published Date

  • September 1, 1995

Published In

Volume / Issue

  • 487 ( Pt 2) / Pt 2

Start / End Page

  • 283 - 289

PubMed ID

  • 8558463

Pubmed Central ID

  • PMC1156572

International Standard Serial Number (ISSN)

  • 0022-3751

Digital Object Identifier (DOI)

  • 10.1113/jphysiol.1995.sp020879


  • eng

Conference Location

  • England