A conserved family of enzymes that phosphorylate inositol hexakisphosphate.
Publication
, Journal Article
Mulugu, S; Bai, W; Fridy, PC; Bastidas, RJ; Otto, JC; Dollins, DE; Haystead, TA; Ribeiro, AA; York, JD
Published in: Science
April 6, 2007
Inositol pyrophosphates are a diverse group of high-energy signaling molecules whose cellular roles remain an active area of study. We report a previously uncharacterized class of inositol pyrophosphate synthase and find it is identical to yeast Vip1 and Asp1 proteins, regulators of actin-related protein-2/3 (ARP 2/3) complexes. Vip1 and Asp1 acted as enzymes that encode inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase activities. Alterations in kinase activity led to defects in cell growth, morphology, and interactions with ARP complex members. The functionality of Asp1 and Vip1 may provide cells with increased signaling capacity through metabolism of IP6.
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Published In
Science
DOI
EISSN
1095-9203
Publication Date
April 6, 2007
Volume
316
Issue
5821
Start / End Page
106 / 109
Location
United States
Related Subject Headings
- Temperature
- Substrate Specificity
- Sequence Alignment
- Schizosaccharomyces pombe Proteins
- Schizosaccharomyces
- Saccharomyces cerevisiae Proteins
- Saccharomyces cerevisiae
- Recombinant Fusion Proteins
- Pyrophosphatases
- Protein Structure, Tertiary
Citation
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Mulugu, S., Bai, W., Fridy, P. C., Bastidas, R. J., Otto, J. C., Dollins, D. E., … York, J. D. (2007). A conserved family of enzymes that phosphorylate inositol hexakisphosphate. Science, 316(5821), 106–109. https://doi.org/10.1126/science.1139099
Mulugu, Sashidhar, Wenli Bai, Peter C. Fridy, Robert J. Bastidas, James C. Otto, D Eric Dollins, Timothy A. Haystead, Anthony A. Ribeiro, and John D. York. “A conserved family of enzymes that phosphorylate inositol hexakisphosphate.” Science 316, no. 5821 (April 6, 2007): 106–9. https://doi.org/10.1126/science.1139099.
Mulugu S, Bai W, Fridy PC, Bastidas RJ, Otto JC, Dollins DE, et al. A conserved family of enzymes that phosphorylate inositol hexakisphosphate. Science. 2007 Apr 6;316(5821):106–9.
Mulugu, Sashidhar, et al. “A conserved family of enzymes that phosphorylate inositol hexakisphosphate.” Science, vol. 316, no. 5821, Apr. 2007, pp. 106–09. Pubmed, doi:10.1126/science.1139099.
Mulugu S, Bai W, Fridy PC, Bastidas RJ, Otto JC, Dollins DE, Haystead TA, Ribeiro AA, York JD. A conserved family of enzymes that phosphorylate inositol hexakisphosphate. Science. 2007 Apr 6;316(5821):106–109.
Published In
Science
DOI
EISSN
1095-9203
Publication Date
April 6, 2007
Volume
316
Issue
5821
Start / End Page
106 / 109
Location
United States
Related Subject Headings
- Temperature
- Substrate Specificity
- Sequence Alignment
- Schizosaccharomyces pombe Proteins
- Schizosaccharomyces
- Saccharomyces cerevisiae Proteins
- Saccharomyces cerevisiae
- Recombinant Fusion Proteins
- Pyrophosphatases
- Protein Structure, Tertiary