A conserved family of enzymes that phosphorylate inositol hexakisphosphate.
Journal Article (Journal Article)
Inositol pyrophosphates are a diverse group of high-energy signaling molecules whose cellular roles remain an active area of study. We report a previously uncharacterized class of inositol pyrophosphate synthase and find it is identical to yeast Vip1 and Asp1 proteins, regulators of actin-related protein-2/3 (ARP 2/3) complexes. Vip1 and Asp1 acted as enzymes that encode inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase activities. Alterations in kinase activity led to defects in cell growth, morphology, and interactions with ARP complex members. The functionality of Asp1 and Vip1 may provide cells with increased signaling capacity through metabolism of IP6.
Full Text
Duke Authors
Cited Authors
- Mulugu, S; Bai, W; Fridy, PC; Bastidas, RJ; Otto, JC; Dollins, DE; Haystead, TA; Ribeiro, AA; York, JD
Published Date
- April 6, 2007
Published In
Volume / Issue
- 316 / 5821
Start / End Page
- 106 - 109
PubMed ID
- 17412958
Electronic International Standard Serial Number (EISSN)
- 1095-9203
Digital Object Identifier (DOI)
- 10.1126/science.1139099
Language
- eng
Conference Location
- United States