Sodium and water regulation in a patient with cerebral salt wasting.

Journal Article (Journal Article)

Hyponatremia, in patients with central nervous system disease, can be attributable to impaired free water excretion (syndrome of inappropriate secretion of antidiuretic hormone) or to excessive sodium excretion (cerebral salt wasting). We present a patient with a parietal glioma and hyponatremia characterized by salt wasting and dehydration. Rehydration and sodium repletion corrected the sodium and volume deficits; withdrawal of supplemental sodium resulted in recurrence of dehydration and hyponatremia. We determined sodium and water balance and measured plasma atriopeptin, antidiuretic hormone, and aldosterone. Plasma atriopeptin ranged from 8 to 44 pg/mL (normal, less than 45 pg/mL); antidiuretic hormone was not elevated at 4 to 5 pg/mL, and aldosterone was slightly elevated at 1040.25 pmol/L. The concentrations of these hormones could not directly explain the natriuresis; interactions with neural or other humoral factors may be involved. In evaluating such patients, careful attention to sodium and water balance is important to guide appropriate therapy.

Full Text

Duke Authors

Cited Authors

  • Diringer, M; Ladenson, PW; Borel, C; Hart, GK; Kirsch, JR; Hanley, DF

Published Date

  • August 1, 1989

Published In

Volume / Issue

  • 46 / 8

Start / End Page

  • 928 - 930

PubMed ID

  • 2757534

International Standard Serial Number (ISSN)

  • 0003-9942

Digital Object Identifier (DOI)

  • 10.1001/archneur.1989.00520440124031


  • eng

Conference Location

  • United States