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Cerebral blood flow velocity response to magnesium sulfate in patients after subarachnoid hemorrhage.

Publication ,  Journal Article
Brewer, RP; Parra, A; Lynch, J; Chilukuri, V; Borel, CO
Published in: J Neurosurg Anesthesiol
July 2001

Magnesium sulfate therapy, standard in preventing seizures in preeclampsia, is under active investigation as a neuroprotective agent. The authors studied the effect of magnesium as a cerebral vasodilator by measuring the cerebral blood flow velocity (CBFV) response to a 5g intravenous bolus of MgSO4 compared with a saline placebo after subarachnoid hemorrhage (SAH). Transcranial Doppler ultrasonography of the middle cerebral artery (MCA) was measured after each infusion. Patients were studied up to three times after SAH at prescribed time intervals. Fourteen patients (11 women, 3 men; mean age 58 years) underwent 29 studies. All patients underwent hypertensive, hypervolemic therapy. Four patients developed cerebral vasospasm. Doubling serum magnesium levels did not affect MCA CBFV but slightly lowered mean arterial blood pressure and systemic vascular resistance. Intravenous magnesium bolus did not reduce elevated CBFV in the subset of SAH patients with clinical vasospasm. The role of magnesium sulfate as a cerebral vasodilator in patients with SAH requires further study.

Duke Scholars

Published In

J Neurosurg Anesthesiol

DOI

ISSN

0898-4921

Publication Date

July 2001

Volume

13

Issue

3

Start / End Page

202 / 206

Location

United States

Related Subject Headings

  • Vasospasm, Intracranial
  • Vascular Resistance
  • Ultrasonography, Doppler, Transcranial
  • Subarachnoid Hemorrhage
  • Pulmonary Artery
  • Postoperative Complications
  • Placebos
  • Middle Cerebral Artery
  • Middle Aged
  • Male
 

Citation

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Brewer, R. P., Parra, A., Lynch, J., Chilukuri, V., & Borel, C. O. (2001). Cerebral blood flow velocity response to magnesium sulfate in patients after subarachnoid hemorrhage. J Neurosurg Anesthesiol, 13(3), 202–206. https://doi.org/10.1097/00008506-200107000-00004
Brewer, R. P., A. Parra, J. Lynch, V. Chilukuri, and C. O. Borel. “Cerebral blood flow velocity response to magnesium sulfate in patients after subarachnoid hemorrhage.J Neurosurg Anesthesiol 13, no. 3 (July 2001): 202–6. https://doi.org/10.1097/00008506-200107000-00004.
Brewer RP, Parra A, Lynch J, Chilukuri V, Borel CO. Cerebral blood flow velocity response to magnesium sulfate in patients after subarachnoid hemorrhage. J Neurosurg Anesthesiol. 2001 Jul;13(3):202–6.
Brewer, R. P., et al. “Cerebral blood flow velocity response to magnesium sulfate in patients after subarachnoid hemorrhage.J Neurosurg Anesthesiol, vol. 13, no. 3, July 2001, pp. 202–06. Pubmed, doi:10.1097/00008506-200107000-00004.
Brewer RP, Parra A, Lynch J, Chilukuri V, Borel CO. Cerebral blood flow velocity response to magnesium sulfate in patients after subarachnoid hemorrhage. J Neurosurg Anesthesiol. 2001 Jul;13(3):202–206.

Published In

J Neurosurg Anesthesiol

DOI

ISSN

0898-4921

Publication Date

July 2001

Volume

13

Issue

3

Start / End Page

202 / 206

Location

United States

Related Subject Headings

  • Vasospasm, Intracranial
  • Vascular Resistance
  • Ultrasonography, Doppler, Transcranial
  • Subarachnoid Hemorrhage
  • Pulmonary Artery
  • Postoperative Complications
  • Placebos
  • Middle Cerebral Artery
  • Middle Aged
  • Male