T cell-mediated elimination of B7.2 transgenic B cells.

Published

Journal Article

Transgenic mice were generated to explore the effects on lymphoid development and immune function of constitutive expression of murine B7.2 on B and T cells. The number of B lymphocytes in primary and secondary lymphoid tissues is normal in B7.2 transgenic lines expressing low levels of B7.2 on B cells, but markedly reduced in transgenic lines expressing moderate to high levels of the transgene on B cells. This reduction is not due to an intrinsic abnormality of the transgenic B cells, but is rather the consequence of an elimination by an immune mechanism requiring the engagement of CD28 on T cells. Interestingly, during cognate antigen-specific interaction with T cells in vivo, B7.2 transgenic B cells are not eliminated, but proliferate and differentiate normally. Our findings suggest that, in the absence of high affinity ligand for the TCR, the CD28-B7.2 system participates in the regulation of B cell homeostasis.

Full Text

Duke Authors

Cited Authors

  • Fournier, S; Rathmell, JC; Goodnow, CC; Allison, JP

Published Date

  • March 1997

Published In

Volume / Issue

  • 6 / 3

Start / End Page

  • 327 - 339

PubMed ID

  • 9075933

Pubmed Central ID

  • 9075933

International Standard Serial Number (ISSN)

  • 1074-7613

Digital Object Identifier (DOI)

  • 10.1016/s1074-7613(00)80335-0

Language

  • eng

Conference Location

  • United States