Pathways of apoptosis in lymphocyte development, homeostasis, and disease.

Journal Article (Journal Article;Review)

Apoptosis plays a critical role in lymphocyte development and homeostasis. Enhanced lymphocyte apoptosis can cause immunodeficiency through cell loss. Conversely, inhibition of apoptosis can lead to the development of autoimmunity or lymphoma. Two major pathways contribute to the regulation of lymphocyte cell death, death-by-neglect and death-by-instruction.

Full Text

Duke Authors

Cited Authors

  • Rathmell, JC; Thompson, CB

Published Date

  • April 2002

Published In

Volume / Issue

  • 109 Suppl /

Start / End Page

  • S97 - 107

PubMed ID

  • 11983156

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/s0092-8674(02)00704-3


  • eng

Conference Location

  • United States