Pathways of apoptosis in lymphocyte development, homeostasis, and disease.
Journal Article (Journal Article;Review)
Apoptosis plays a critical role in lymphocyte development and homeostasis. Enhanced lymphocyte apoptosis can cause immunodeficiency through cell loss. Conversely, inhibition of apoptosis can lead to the development of autoimmunity or lymphoma. Two major pathways contribute to the regulation of lymphocyte cell death, death-by-neglect and death-by-instruction.
Full Text
Duke Authors
Cited Authors
- Rathmell, JC; Thompson, CB
Published Date
- April 2002
Published In
Volume / Issue
- 109 Suppl /
Start / End Page
- S97 - 107
PubMed ID
- 11983156
International Standard Serial Number (ISSN)
- 0092-8674
Digital Object Identifier (DOI)
- 10.1016/s0092-8674(02)00704-3
Language
- eng
Conference Location
- United States