Homeostatic control of lymphocyte survival: potential origins and implications.

Journal Article (Journal Article;Review)

Lymphocytes depend on extracellular ligands to maintain their viability. Structurally diverse lymphocyte receptors transmit survival signals through separate signal transduction cascades, which all share the ability to sustain viability by maintaining the sequestration of apoptogenic factors within mitochondria. Receptors can induce cellular survival either by promoting the expression and/or function of anti-apoptotic Bcl-2 family proteins or by activating the phosphatidylinositol-3 kinase Akt pathway. Either of these events represses the function of the pro-apoptotic proteins Bax and Bak, which are required for mitochondrial release of cytochrome c. As we discuss here, the apparently redundant functions of Bax and Bak may have evolved to prevent lymphocyte mitochondria from adapting to loss of receptor mediated signal transduction and thus keep lymphocytes from accumulating in a cell-autonomous manner.

Full Text

Duke Authors

Cited Authors

  • Plas, DR; Rathmell, JC; Thompson, CB

Published Date

  • June 2002

Published In

Volume / Issue

  • 3 / 6

Start / End Page

  • 515 - 521

PubMed ID

  • 12032565

International Standard Serial Number (ISSN)

  • 1529-2908

Digital Object Identifier (DOI)

  • 10.1038/ni0602-515


  • eng

Conference Location

  • United States