The CD28 signaling pathway regulates glucose metabolism.

Published

Journal Article

Lymphocyte activation initiates a program of cell growth, proliferation, and differentiation that increases metabolic demand. Although T cells increase glucose uptake and glycolysis during an immune response, the signaling pathways that regulate these increases remain largely unknown. Here we show that CD28 costimulation, acting through phosphatidylinositol 3'-kinase (PI3K) and Akt, is required for T cells to increase their glycolytic rate in response to activation. Furthermore, CD28 controls a primary response pathway, inducing a level of glucose uptake and glycolysis in excess of that needed to maintain cellular ATP/ADP levels or macromolecular synthesis. These data suggest that CD28 costimulation functions to increase glycolytic flux, allowing T cells to anticipate energetic and biosynthetic needs associated with a sustained response.

Full Text

Duke Authors

Cited Authors

  • Frauwirth, KA; Riley, JL; Harris, MH; Parry, RV; Rathmell, JC; Plas, DR; Elstrom, RL; June, CH; Thompson, CB

Published Date

  • June 2002

Published In

Volume / Issue

  • 16 / 6

Start / End Page

  • 769 - 777

PubMed ID

  • 12121659

Pubmed Central ID

  • 12121659

Electronic International Standard Serial Number (EISSN)

  • 1097-4180

International Standard Serial Number (ISSN)

  • 1074-7613

Digital Object Identifier (DOI)

  • 10.1016/s1074-7613(02)00323-0

Language

  • eng