Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells.

Published

Journal Article

Despite expression of the high-affinity IL-2R, CD4(+)CD25(+) regulatory T cells (Tregs) are hypoproliferative upon IL-2R stimulation in vitro. However the mechanisms by which CD4(+)CD25(+) T cells respond to IL-2 signals are undefined. In this report, we examine the cellular and molecular responses of CD4(+)CD25(+) Tregs to IL-2. IL-2R stimulation results in a G(1) cell cycle arrest, cellular enlargement and increased cellular survival of CD4(+)CD25(+) T cells. We find a distinct pattern of IL-2R signaling in which the Janus kinase/STAT pathway remains intact, whereas IL-2 does not activate downstream targets of phosphatidylinositol 3-kinase. Negative regulation of phosphatidylinositol 3-kinase signaling and IL-2-mediated proliferation of CD4(+)CD25(+) T cells is inversely associated with expression of the phosphatase and tensin homologue deleted on chromosome 10, PTEN.

Full Text

Duke Authors

Cited Authors

  • Bensinger, SJ; Walsh, PT; Zhang, J; Carroll, M; Parsons, R; Rathmell, JC; Thompson, CB; Burchill, MA; Farrar, MA; Turka, LA

Published Date

  • May 1, 2004

Published In

Volume / Issue

  • 172 / 9

Start / End Page

  • 5287 - 5296

PubMed ID

  • 15100267

Pubmed Central ID

  • 15100267

International Standard Serial Number (ISSN)

  • 0022-1767

Digital Object Identifier (DOI)

  • 10.4049/jimmunol.172.9.5287

Language

  • eng

Conference Location

  • United States