Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells.
Published
Journal Article
Despite expression of the high-affinity IL-2R, CD4(+)CD25(+) regulatory T cells (Tregs) are hypoproliferative upon IL-2R stimulation in vitro. However the mechanisms by which CD4(+)CD25(+) T cells respond to IL-2 signals are undefined. In this report, we examine the cellular and molecular responses of CD4(+)CD25(+) Tregs to IL-2. IL-2R stimulation results in a G(1) cell cycle arrest, cellular enlargement and increased cellular survival of CD4(+)CD25(+) T cells. We find a distinct pattern of IL-2R signaling in which the Janus kinase/STAT pathway remains intact, whereas IL-2 does not activate downstream targets of phosphatidylinositol 3-kinase. Negative regulation of phosphatidylinositol 3-kinase signaling and IL-2-mediated proliferation of CD4(+)CD25(+) T cells is inversely associated with expression of the phosphatase and tensin homologue deleted on chromosome 10, PTEN.
Full Text
Duke Authors
Cited Authors
- Bensinger, SJ; Walsh, PT; Zhang, J; Carroll, M; Parsons, R; Rathmell, JC; Thompson, CB; Burchill, MA; Farrar, MA; Turka, LA
Published Date
- May 1, 2004
Published In
Volume / Issue
- 172 / 9
Start / End Page
- 5287 - 5296
PubMed ID
- 15100267
Pubmed Central ID
- 15100267
International Standard Serial Number (ISSN)
- 0022-1767
Digital Object Identifier (DOI)
- 10.4049/jimmunol.172.9.5287
Language
- eng
Conference Location
- United States