Bovine phospholipase C highly homologous to the norpA protein of Drosophila is expressed specifically in cones.

Journal Article

The Drosophila norpA gene encodes a phosphatidylinositol-specific phospholipase C (PI-PLC) expressed predominantly in photoreceptors and involved in phototransduction. However, no direct role for a phospholipase C in vertebrate phototransduction has been identified to date. Recently, we reported the isolation and characterization of bovine cDNAs encoding PI-PLC isoforms expressed predominantly in the retina and with higher homology to the NorpA protein than to any other known PI-PLC. Here, we present evidence that the norpA-homologous bovine retinal PI-PLCs, although found in other retinal neurons as well, are found in cones but not in rods. The results suggest that the phototransduction cascade in cones may utilize phospholipase C in addition to phosphodiesterase.

Full Text

Duke Authors

Cited Authors

  • Ferreira, PA; Pak, WL

Published Date

  • February 4, 1994

Published In

Volume / Issue

  • 269 / 5

Start / End Page

  • 3129 - 3131

PubMed ID

  • 8106345

International Standard Serial Number (ISSN)

  • 0021-9258

Language

  • eng

Conference Location

  • United States