Resolution of lung inflammation by CD44.


Journal Article

Successful repair after tissue injury and inflammation requires resolution of the inflammatory response and removal of extracellular matrix breakdown products. We have examined whether the cell-surface adhesion molecule and hyaluronan receptor CD44 plays a role in resolving lung inflammation. CD44-deficient mice succumb to unremitting inflammation following noninfectious lung injury, characterized by impaired clearance of apoptotic neutrophils, persistent accumulation of hyaluronan fragments at the site of tissue injury, and impaired activation of transforming growth factor-beta1. This phenotype was partially reversed by reconstitution with CD44+ cells, thus demonstrating a critical role for this receptor in resolving lung inflammation.

Full Text

Cited Authors

  • Teder, P; Vandivier, RW; Jiang, D; Liang, J; Cohn, L; Puré, E; Henson, PM; Noble, PW

Published Date

  • April 2002

Published In

Volume / Issue

  • 296 / 5565

Start / End Page

  • 155 - 158

PubMed ID

  • 11935029

Pubmed Central ID

  • 11935029

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1069659


  • eng