On the complexity of investigating chronic illness.

Journal Article (Clinical Trial;Journal Article)

Chronic diseases are in many ways more complex than acute diseases. In chronic diseases, response times to environmental effects are long, and confounding variables are numerous and may fluctuate with time. Treatment schedules are complicated and may be unique to the individual patient. Controlled trials deal with rigid hypotheses and permit control of error rates; prospective registries permit access to homogeneous subgroups. There is now a need for a new methodology for the study of the treatment of chronic diseases, which combines the merits of both approaches.

Full Text

Duke Authors

Cited Authors

  • Starmer, CF; Lee, KL; Harrell, FE; Rosati, RA

Published Date

  • June 1980

Published In

Volume / Issue

  • 36 / 2

Start / End Page

  • 333 - 335

PubMed ID

  • 6996753

International Standard Serial Number (ISSN)

  • 0006-341X


  • eng

Conference Location

  • United States