The quantitative investigation of the binding process of calcium blocking drugs in a sinoatrial node.

Journal Article (Journal Article)

Application of existing models of sinoatrial node pacemaker activity and of channel-drug interaction allow us to reproduce action potential changes as a result of the blocking effect of drugs. Two calcium antagonistic drugs, nifedipine and mesudipine, were investigated and as a result averaged rate constants of binding and unbinding were evaluated. The procedure applied which is based on experimental results and on computer simulations, can be used as an initial step for comparison of different drugs.

Full Text

Duke Authors

Cited Authors

  • Plonsey, R; Starmer, CF; Tipans, I

Published Date

  • March 1, 1991

Published In

Volume / Issue

  • 149 / 1

Start / End Page

  • 55 - 61

PubMed ID

  • 1881146

Electronic International Standard Serial Number (EISSN)

  • 1095-8541

International Standard Serial Number (ISSN)

  • 0022-5193

Digital Object Identifier (DOI)

  • 10.1016/s0022-5193(05)80071-2


  • eng