Scholars@Duke publication: The quantitative investigation of the binding process of calcium blocking drugs in a sinoatrial node.

The quantitative investigation of the binding process of calcium blocking drugs in a sinoatrial node.

Publication , Journal Article

Plonsey, R; Starmer, CF; Tipans, I

Published in: Journal of theoretical biology

March 1991

Application of existing models of sinoatrial node pacemaker activity and of channel-drug interaction allow us to reproduce action potential changes as a result of the blocking effect of drugs. Two calcium antagonistic drugs, nifedipine and mesudipine, were investigated and as a result averaged rate constants of binding and unbinding were evaluated. The procedure applied which is based on experimental results and on computer simulations, can be used as an initial step for comparison of different drugs.

Duke Scholars

Author Charles Franklin Starmer Computer Science

Published In

Journal of theoretical biology

DOI

10.1016/s0022-5193(05)80071-2

EISSN

1095-8541

ISSN

0022-5193

Publication Date

March 1991

Volume

149

Issue

Start / End Page

55 / 61

Related Subject Headings

Sinoatrial Node
Rabbits
Nifedipine
Models, Biological
Evolutionary Biology
Computer Simulation
Calcium Channel Blockers
Animals
Action Potentials
49 Mathematical sciences

Citation

APA

Chicago

ICMJE

MLA

NLM

Plonsey, R., Starmer, C. F., & Tipans, I. (1991). The quantitative investigation of the binding process of calcium blocking drugs in a sinoatrial node. Journal of Theoretical Biology, 149(1), 55–61. https://doi.org/10.1016/s0022-5193(05)80071-2

Plonsey, R., C. F. Starmer, and I. Tipans. “The quantitative investigation of the binding process of calcium blocking drugs in a sinoatrial node.” Journal of Theoretical Biology 149, no. 1 (March 1991): 55–61. https://doi.org/10.1016/s0022-5193(05)80071-2.

Plonsey R, Starmer CF, Tipans I. The quantitative investigation of the binding process of calcium blocking drugs in a sinoatrial node. Journal of theoretical biology. 1991 Mar;149(1):55–61.

Plonsey, R., et al. “The quantitative investigation of the binding process of calcium blocking drugs in a sinoatrial node.” Journal of Theoretical Biology, vol. 149, no. 1, Mar. 1991, pp. 55–61. Epmc, doi:10.1016/s0022-5193(05)80071-2.

Plonsey R, Starmer CF, Tipans I. The quantitative investigation of the binding process of calcium blocking drugs in a sinoatrial node. Journal of theoretical biology. 1991 Mar;149(1):55–61.