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Quinidine blocks adenosine 5'-triphosphate-sensitive potassium channels in heart.

Publication ,  Journal Article
Undrovinas, AI; Burnashev, N; Eroshenko, D; Fleidervish, I; Starmer, CF; Makielski, JC; Rosenshtraukh, LV
Published in: The American journal of physiology
November 1990

The ATP-sensitive potassium channel current (IK-ATP) was studied in excised inside-out patches from rat ventricular cells at 20-23 degrees C. The bath solution contained 140 mM KF, and the pipette solution contained 140 mM KCl and 1.2 mM MgCl2. ATP (0.5 mM) in the bath inhibited IK-ATP. In the absence of ATP, 10 microM quinidine decreased open probability 67 +/- 1% (n = 6) at -50 mV and 28 +/- 12% at -130 mV (n = 5) without affecting single channel conductance (48-52 pS). The block increased with 25 and 50 microM quinidine and could be reversed on washing quinidine for several minutes. Interburst (closed) intervals were increased by quinidine, whereas open and closed time distributions within bursts were not changed. We conclude that quinidine blocks IK-ATP in a "slow" and voltage-dependent manner in clinically relevant concentrations. Because of the postulated role for IK-ATP in cardiac ischemia, quinidine block of this channel may play a role in ischemic arrhythmias.

Duke Scholars

Published In

The American journal of physiology

DOI

EISSN

2163-5773

ISSN

0002-9513

Publication Date

November 1990

Volume

259

Issue

5 Pt 2

Start / End Page

H1609 / H1612

Related Subject Headings

  • Quinidine
  • Potassium Channels
  • Osmolar Concentration
  • Myocardium
  • Kinetics
  • Electrophysiology
  • Cardiovascular System & Hematology
  • Animals
  • Adenosine Triphosphate
 

Citation

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Undrovinas, A. I., Burnashev, N., Eroshenko, D., Fleidervish, I., Starmer, C. F., Makielski, J. C., & Rosenshtraukh, L. V. (1990). Quinidine blocks adenosine 5'-triphosphate-sensitive potassium channels in heart. The American Journal of Physiology, 259(5 Pt 2), H1609–H1612. https://doi.org/10.1152/ajpheart.1990.259.5.h1609
Undrovinas, A. I., N. Burnashev, D. Eroshenko, I. Fleidervish, C. F. Starmer, J. C. Makielski, and L. V. Rosenshtraukh. “Quinidine blocks adenosine 5'-triphosphate-sensitive potassium channels in heart.The American Journal of Physiology 259, no. 5 Pt 2 (November 1990): H1609–12. https://doi.org/10.1152/ajpheart.1990.259.5.h1609.
Undrovinas AI, Burnashev N, Eroshenko D, Fleidervish I, Starmer CF, Makielski JC, et al. Quinidine blocks adenosine 5'-triphosphate-sensitive potassium channels in heart. The American journal of physiology. 1990 Nov;259(5 Pt 2):H1609–12.
Undrovinas, A. I., et al. “Quinidine blocks adenosine 5'-triphosphate-sensitive potassium channels in heart.The American Journal of Physiology, vol. 259, no. 5 Pt 2, Nov. 1990, pp. H1609–12. Epmc, doi:10.1152/ajpheart.1990.259.5.h1609.
Undrovinas AI, Burnashev N, Eroshenko D, Fleidervish I, Starmer CF, Makielski JC, Rosenshtraukh LV. Quinidine blocks adenosine 5'-triphosphate-sensitive potassium channels in heart. The American journal of physiology. 1990 Nov;259(5 Pt 2):H1609–H1612.

Published In

The American journal of physiology

DOI

EISSN

2163-5773

ISSN

0002-9513

Publication Date

November 1990

Volume

259

Issue

5 Pt 2

Start / End Page

H1609 / H1612

Related Subject Headings

  • Quinidine
  • Potassium Channels
  • Osmolar Concentration
  • Myocardium
  • Kinetics
  • Electrophysiology
  • Cardiovascular System & Hematology
  • Animals
  • Adenosine Triphosphate