Sudden death due to coronary artery disease. A clinical, hemodynamic, and angiographic profile.

Journal Article (Journal Article)

The authors followed 536 medically managed patients with angiographically documented coronary artery disease for up to 4 years, and examined antemortem clinical, anatomical, and hemodynamic characteristics of the 29 patients who died suddenly during the follow-up period. These patients are compared in terms of hemodynamic characteristics to those who survived and those who died non-suddenly of coronary heart disease. Of the 29 patients who died suddenly, more than 80% had evidence of moderate to severe impairment of myocardial function many months prior to death. Only a single patient had the combination of relatively mild coronary artery disease and normal ventricular function. This single patient would be the ultimate target of a program designed to prevent sudden death. However, it has been necessary to follow 536 patients with angiographically documented coronary artery disease in order to find this one potential benefactor of sudden death prophylaxis. This study demonstrates that there are patients with coronary artery disease who die suddenly, despite relatively mild disease; however, these patients appear to represent only a small proportion of all sudden deaths.

Full Text

Duke Authors

Cited Authors

  • Margolis, JR; Hirshfeld, JW; McNeer, JF; Starmer, CF; Rosati, RA; Peter, RH; Behar, VS; Kong, Y

Published Date

  • December 1, 1975

Published In

Volume / Issue

  • 52 / 6 Suppl

Start / End Page

  • III180 - III188

PubMed ID

  • 1182973

International Standard Serial Number (ISSN)

  • 0009-7322


  • eng

Conference Location

  • United States