Assignment of the beta-subunit of rod photoreceptor cGMP phosphodiesterase gene PDEB (homolog of the mouse rd gene) to human chromosome 4p16.

Published

Journal Article

The gene encoding the beta-subunit of rod photoreceptor cGMP phosphodiesterase (gene symbol PDEB, homolog of the mouse rd gene) is mapped to human chromosome 4 using somatic cell hybrids and further localized to the chromosome band 4p16 using in situ hybridization. A mutation in the mouse gene underlies the recessive trait of retinal degeneration in the rd mouse. Thus, the human homolog is a candidate for lesions causing retinal degeneration.

Full Text

Duke Authors

Cited Authors

  • Bateman, JB; Klisak, I; Kojis, T; Mohandas, T; Sparkes, RS; Li, TS; Applebury, ML; Bowes, C; Farber, DB

Published Date

  • March 1992

Published In

Volume / Issue

  • 12 / 3

Start / End Page

  • 601 - 603

PubMed ID

  • 1313787

Pubmed Central ID

  • 1313787

International Standard Serial Number (ISSN)

  • 0888-7543

Digital Object Identifier (DOI)

  • 10.1016/0888-7543(92)90454-z

Language

  • eng

Conference Location

  • United States