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Assignment of the beta-subunit of rod photoreceptor cGMP phosphodiesterase gene PDEB (homolog of the mouse rd gene) to human chromosome 4p16.

Publication ,  Journal Article
Bateman, JB; Klisak, I; Kojis, T; Mohandas, T; Sparkes, RS; Li, TS; Applebury, ML; Bowes, C; Farber, DB
Published in: Genomics
March 1992

The gene encoding the beta-subunit of rod photoreceptor cGMP phosphodiesterase (gene symbol PDEB, homolog of the mouse rd gene) is mapped to human chromosome 4 using somatic cell hybrids and further localized to the chromosome band 4p16 using in situ hybridization. A mutation in the mouse gene underlies the recessive trait of retinal degeneration in the rd mouse. Thus, the human homolog is a candidate for lesions causing retinal degeneration.

Duke Scholars

Published In

Genomics

DOI

ISSN

0888-7543

Publication Date

March 1992

Volume

12

Issue

3

Start / End Page

601 / 603

Location

United States

Related Subject Headings

  • Photoreceptor Cells
  • Mice
  • Macromolecular Substances
  • Hybrid Cells
  • Humans
  • Genetics & Heredity
  • Chromosomes, Human, Pair 4
  • Chromosome Banding
  • Biological Evolution
  • Animals
 

Citation

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ICMJE
MLA
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Bateman, J. B., Klisak, I., Kojis, T., Mohandas, T., Sparkes, R. S., Li, T. S., … Farber, D. B. (1992). Assignment of the beta-subunit of rod photoreceptor cGMP phosphodiesterase gene PDEB (homolog of the mouse rd gene) to human chromosome 4p16. Genomics, 12(3), 601–603. https://doi.org/10.1016/0888-7543(92)90454-z
Bateman, J. B., I. Klisak, T. Kojis, T. Mohandas, R. S. Sparkes, T. S. Li, M. L. Applebury, C. Bowes, and D. B. Farber. “Assignment of the beta-subunit of rod photoreceptor cGMP phosphodiesterase gene PDEB (homolog of the mouse rd gene) to human chromosome 4p16.Genomics 12, no. 3 (March 1992): 601–3. https://doi.org/10.1016/0888-7543(92)90454-z.
Bateman JB, Klisak I, Kojis T, Mohandas T, Sparkes RS, Li TS, et al. Assignment of the beta-subunit of rod photoreceptor cGMP phosphodiesterase gene PDEB (homolog of the mouse rd gene) to human chromosome 4p16. Genomics. 1992 Mar;12(3):601–3.
Bateman, J. B., et al. “Assignment of the beta-subunit of rod photoreceptor cGMP phosphodiesterase gene PDEB (homolog of the mouse rd gene) to human chromosome 4p16.Genomics, vol. 12, no. 3, Mar. 1992, pp. 601–03. Pubmed, doi:10.1016/0888-7543(92)90454-z.
Bateman JB, Klisak I, Kojis T, Mohandas T, Sparkes RS, Li TS, Applebury ML, Bowes C, Farber DB. Assignment of the beta-subunit of rod photoreceptor cGMP phosphodiesterase gene PDEB (homolog of the mouse rd gene) to human chromosome 4p16. Genomics. 1992 Mar;12(3):601–603.
Journal cover image

Published In

Genomics

DOI

ISSN

0888-7543

Publication Date

March 1992

Volume

12

Issue

3

Start / End Page

601 / 603

Location

United States

Related Subject Headings

  • Photoreceptor Cells
  • Mice
  • Macromolecular Substances
  • Hybrid Cells
  • Humans
  • Genetics & Heredity
  • Chromosomes, Human, Pair 4
  • Chromosome Banding
  • Biological Evolution
  • Animals