Cell-surface co-receptors: emerging roles in signaling and human disease.

Journal Article (Journal Article;Review)

Extracellular signals are transmitted to cells through two classes of cell-surface receptors: signaling receptors that directly transduce signals and signaling co-receptors that bind ligand but that, traditionally, have not been thought to signal directly. Signaling co-receptors modulate the ligand binding and signaling of their respective signaling receptors. In recent years, roles for co-receptors have expanded to include essential functions in morphogen gradient formation, localizing signaling, signaling independently, regulating cell adhesion and orchestrating the signaling of several pathways. The importance of signaling co-receptors is demonstrated by their ubiquitous expression, their conservation during evolution, their prominent role in signaling cascades, their indispensable role during development and their frequent mutation or altered expression in human disease.

Full Text

Duke Authors

Cited Authors

  • Kirkbride, KC; Ray, BN; Blobe, GC

Published Date

  • November 2005

Published In

Volume / Issue

  • 30 / 11

Start / End Page

  • 611 - 621

PubMed ID

  • 16185874

International Standard Serial Number (ISSN)

  • 0968-0004

Digital Object Identifier (DOI)

  • 10.1016/j.tibs.2005.09.003


  • eng

Conference Location

  • England