Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop.

Journal Article (Journal Article)

CD19 and CD22 are B lymphocyte cell-surface molecules that positively and negatively regulate antigen receptor signal transduction, respectively. Biochemical studies with B cells from CD19-deficient and CD22-deficient mice indicated that these two regulatory molecules influenced each other's functions: CD22 expression negatively regulated CD19 tyrosine phosphorylation, while optimal CD22 function was dependent on CD19 expression. Functional CD19 and CD22 interactions were also assessed in vivo by generating CD19/CD22 double-deficient mice. Remarkably, the CD19 mutation was dominant to the CD22 mutation in most instances. B lymphocytes from CD19/CD22-deficient and CD19-deficient mice were functionally equivalent despite the negative influence normally provided by CD22 expression. These data collectively suggest that CD19 activates the CD22/SHP1 inhibitory pathway that then acts primarily on CD19.

Full Text

Duke Authors

Cited Authors

  • Fujimoto, M; Bradney, AP; Poe, JC; Steeber, DA; Tedder, TF

Published Date

  • August 1999

Published In

Volume / Issue

  • 11 / 2

Start / End Page

  • 191 - 200

PubMed ID

  • 10485654

International Standard Serial Number (ISSN)

  • 1074-7613

Digital Object Identifier (DOI)

  • 10.1016/s1074-7613(00)80094-1


  • eng

Conference Location

  • United States