CD19 regulates B lymphocyte responses to transmembrane signals.

Published

Journal Article (Review)

CD19 is a component of a cell surface receptor complex that regulates B lymphocyte responses to transmembrane signals including those generated through the B cell antigen receptor. Studies in mice which lack or overexpress CD19 show that changes in CD19 expression levels have significant effects on B cell development and function. Recent studies suggest that CD19 establishes a Src-family kinase activation loop that amplifies tyrosine phosphorylation of numerous downstream effector molecules including potentially positive and negative regulatory elements. These observations provide an understanding of how CD19 governs the molecular ordering and intensity of signals transduced through multiple B cell receptors.

Full Text

Duke Authors

Cited Authors

  • Fujimoto, M; Poe, JC; Inaoki, M; Tedder, TF

Published Date

  • August 1998

Published In

Volume / Issue

  • 10 / 4

Start / End Page

  • 267 - 277

PubMed ID

  • 9695183

Pubmed Central ID

  • 9695183

International Standard Serial Number (ISSN)

  • 1044-5323

Digital Object Identifier (DOI)

  • 10.1006/smim.1998.9999

Language

  • eng

Conference Location

  • England