CD19 regulates B lymphocyte responses to transmembrane signals.
Journal Article (Journal Article;Review)
CD19 is a component of a cell surface receptor complex that regulates B lymphocyte responses to transmembrane signals including those generated through the B cell antigen receptor. Studies in mice which lack or overexpress CD19 show that changes in CD19 expression levels have significant effects on B cell development and function. Recent studies suggest that CD19 establishes a Src-family kinase activation loop that amplifies tyrosine phosphorylation of numerous downstream effector molecules including potentially positive and negative regulatory elements. These observations provide an understanding of how CD19 governs the molecular ordering and intensity of signals transduced through multiple B cell receptors.
Full Text
Duke Authors
Cited Authors
- Fujimoto, M; Poe, JC; Inaoki, M; Tedder, TF
Published Date
- August 1998
Published In
Volume / Issue
- 10 / 4
Start / End Page
- 267 - 277
PubMed ID
- 9695183
International Standard Serial Number (ISSN)
- 1044-5323
Digital Object Identifier (DOI)
- 10.1006/smim.1998.9999
Language
- eng
Conference Location
- England