Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses.

Journal Article (Journal Article)

The CD21/35 receptor provides an important link between innate and adaptive immunity. Its importance during protective immune responses to encapsulated extracellular bacteria was assessed using a new line of mice completely deficient in CD21/35 expression (CD21/35(-/-)). CD21/35 expression was essential for the rapid trapping of C3dg-antigen complexes by B cells in vivo, especially in splenic marginal zones. Despite normal B cell development in CD21/35(-/-) mice, T cell-independent and -dependent antibody responses to low-dose antigens were significantly decreased, with a striking impairment in IgG3 responses. Accordingly, CD21/35(-/-) mice were more susceptible to acute lethal Streptococcus pneumoniae infection. Thus, CD21/35 expression is critical for early protective antibody responses to lethal pathogens that rapidly multiply and quickly overwhelm the immune system.

Full Text

Duke Authors

Cited Authors

  • Haas, KM; Hasegawa, M; Steeber, DA; Poe, JC; Zabel, MD; Bock, CB; Karp, DR; Briles, DE; Weis, JH; Tedder, TF

Published Date

  • December 2002

Published In

Volume / Issue

  • 17 / 6

Start / End Page

  • 713 - 723

PubMed ID

  • 12479818

International Standard Serial Number (ISSN)

  • 1074-7613

Digital Object Identifier (DOI)

  • 10.1016/s1074-7613(02)00483-1


  • eng

Conference Location

  • United States