Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo.

Journal Article (Journal Article)

Tritiated acetylcholine was used to measure binding sites with characteristics of nicotinic cholinergic receptors in rat brain. Regulation of the binding sites in vivo was examined by administering two drugs that stimulate nicotinic receptors directly or indirectly. After 10 days of exposure to the cholinesterase inhibitor diisopropyl fluorophosphate, binding of tritiated acetylcholine in the cerebral cortex was decreased. However, after repeated administration of nicotine for 10 days, binding of tritiated acetylcholine in the cortex was increased. Saturation analysis of tritiated acetylcholine binding in the cortices of rats treated with diisopropyl fluorophosphate or nicotine indicated that the number of binding sites decreased and increased, respectively, while the affinity of the sites was unaltered.

Full Text

Duke Authors

Cited Authors

  • Schwartz, RD; Kellar, KJ

Published Date

  • April 8, 1983

Published In

Volume / Issue

  • 220 / 4593

Start / End Page

  • 214 - 216

PubMed ID

  • 6828889

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.6828889


  • eng

Conference Location

  • United States