Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo.
Journal Article (Journal Article)
Tritiated acetylcholine was used to measure binding sites with characteristics of nicotinic cholinergic receptors in rat brain. Regulation of the binding sites in vivo was examined by administering two drugs that stimulate nicotinic receptors directly or indirectly. After 10 days of exposure to the cholinesterase inhibitor diisopropyl fluorophosphate, binding of tritiated acetylcholine in the cerebral cortex was decreased. However, after repeated administration of nicotine for 10 days, binding of tritiated acetylcholine in the cortex was increased. Saturation analysis of tritiated acetylcholine binding in the cortices of rats treated with diisopropyl fluorophosphate or nicotine indicated that the number of binding sites decreased and increased, respectively, while the affinity of the sites was unaltered.
Full Text
Duke Authors
Cited Authors
- Schwartz, RD; Kellar, KJ
Published Date
- April 8, 1983
Published In
Volume / Issue
- 220 / 4593
Start / End Page
- 214 - 216
PubMed ID
- 6828889
Pubmed Central ID
- 6828889
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.6828889
Language
- eng
Conference Location
- United States