Protein serine/threonine phosphatases: life, death, and sleeping.

Journal Article (Review)

Protein serine/threonine phosphatases control key biological pathways including early embryonic development, cell proliferation, cell death, circadian rhythm and cancer. Recent studies have provided important insights into how several of the many phosphatase regulators, through their interaction with a conserved phosphatase catalytic subunit, control the activity of critical substrates in these diverse pathways. Recent co-crystal structures provided a major insight into how the diverse protein serine/threonine regulators rein in the otherwise promiscuous catalytic subunits.

Full Text

Duke Authors

Cited Authors

  • Gallego, M; Virshup, DM

Published Date

  • April 2005

Published In

Volume / Issue

  • 17 / 2

Start / End Page

  • 197 - 202

PubMed ID

  • 15780597

International Standard Serial Number (ISSN)

  • 0955-0674

Digital Object Identifier (DOI)

  • 10.1016/j.ceb.2005.01.002

Language

  • eng

Conference Location

  • England