After hours keeps clock researchers CRYing Overtime.

Journal Article (Journal Article)

Three recent reports, including one in this issue of Cell, reveal that the circadian regulator CRY is targeted for degradation by the F box E3 ubiquitin ligase FBXL3 (Siepka et al., 2007; Busino et al., 2007; Godinho et al., 2007). These studies confirm the importance of targeted protein degradation as a key design feature of the mammalian circadian clock.

Full Text

Duke Authors

Cited Authors

  • Virshup, DM; Forger, DB

Published Date

  • June 1, 2007

Published In

Volume / Issue

  • 129 / 5

Start / End Page

  • 857 - 859

PubMed ID

  • 17540165

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2007.05.015


  • eng

Conference Location

  • United States